高通量血液透析对维持性血液透析患者微炎症状态的影响

徐丰博; 孙懿; 刘惠兰

doi:10.3969/j.issn.1671-4091.2011.03.00

中国血液净化 >

2011 , Vol. 10 >Issue 3: 133 - 135

DOI: https://doi.org/10.3969/j.issn.1671-4091.2011.03.00

临床研究

高通量血液透析对维持性血液透析患者微炎症状态的影响

徐丰博 ,
孙懿 ,
刘惠兰

展开

首都医科大学附属复兴医院肾内科

收稿日期: 2010-07-08

修回日期: 1900-01-01

网络出版日期: 2011-03-12

收起

Changes of microinflammatory state in hemodialysis patients using high-flux membrane dialyzer

XU Feng-bo ,
SUN Yi ,
LIU Hui-lan

Expand

Department of Nephrology, Fuxing Hospital, Capital University of Medical Science, Beijing 100038, China

Received date: 2010-07-08

Revised date: 1900-01-01

Online published: 2011-03-12

Fold

摘要

目的前瞻性研究高通量血液透析对患者微炎症状况的影响。方法前瞻性、自身对照研究。30例维持性常规低通量血液透析患者转换为高通量血液透析12个月。治疗0个月(治疗前)、6个月、12个月分别测定血中高敏C反应蛋白、白细胞介素1和白细胞介素6。结果转换为高通量透析12个月后，血清白细胞介素6水平明显下降(P＜0.05)，高敏感C反应蛋白和白细胞介素1水平较前无明显变化。结论长时间高通量血液透析不会加剧透析患者体内微炎症状态，而且可能对微炎症状态有一定改善作用。

关键词： 高通量血液透析; 高敏C反应蛋白; 白细胞介素1; 白细胞介素6

本文引用格式

徐丰博 , 孙懿 , 刘惠兰 . 高通量血液透析对维持性血液透析患者微炎症状态的影响[J]. 中国血液净化, 2011 , 10(3) : 133 -135 . DOI: 10.3969/j.issn.1671-4091.2011.03.00

Abstract

Objective This is a prospective and self-controlled study designed to detect whether the microinflammatory state improves in hemodialysis patients using high-flux dialysis. Methods Thirty patients on maintenance low-flux hemodialysis were included in this study. They were then switched the dialyzer from low-flux dialyzer to high-flux F60 or FX60 dialyzer without changes of dialysis prescription. Ultrapure dialysate was used in the dialysis. Serum high sensitivity C-reactive protein (hCRP), interleukin-1 (IL-1), interleukin-6 (IL-6) and albumin were determined after the switch for 0, 6 and 12 months. Results After the switch from low-flux hemodialysis to high-flux hemodialysis for 12 months, serum hCRP and IL-1 remained unchanged. Serum IL-6 was 39.97±41.03ng/L, 36.81±37.09ng/L and 15.17±1.54ng/L (P<0.05) after the switch for 0, 6 and 12 months, respectively. Conclusions Switch from low-flux hemodialysis to high-flux hemodialysis may improve the microinflammatory state in maintenance hemodialysis patients.

Key words： High sensitivity C-reactive protein; Interleukin-1; Interleukin-6

Options

文章导航

模态框（Modal）标题

摘要

本文引用格式

Abstract