【摘要】目的 调查评估慢性肾脏病（chronic kidney disease，CKD）患者健康相关的生活质量，并探讨可能影响CKD患者健康相关生活质量的因素。 方法 应用欧洲五维健康量表（The EuroQol Group’s 5-domain 3 level questionnaire，EQ-5D-3L），对CKD患者进行问卷调查，同时收集被调查者一般信息及临床实验室检验结果，并采用相关性检验分析影响CKD患者生活质量的因素。 结果 EQ-5D-3L中可视化评分（visual analogue scale，VAS）得分情况与健康描述系统评估结果一致，且VAS得分与年龄、血肌酐（Scr）、尿素氮（BUN）、胱抑素C（CysC）、血磷（P）、钙磷乘积（Ca•P）、铁蛋白、尿蛋白/尿肌酐呈负相关，与估算的肾小球滤过率（eGFR）、血红蛋白（Hb）、白蛋白（Alb）、载脂蛋白A1（ApoA1）呈正相关。结论 本中心应用EQ-5D-3L进行的调查提示，CKD患者中女性更容易出现焦虑沮丧状态，肾功能情况、贫血及微炎症状态对患者生活质量的影响较为显著，也进一步验证这一简明易行的量表反映肾脏病患者的健康相关的生活质量的效能。

【Abstract】 Objective: To investigate the health- related quality of life in patients with chronic kidney disease(CKD), and analysis the possible relating factors of this disease. Methods：The Chinese version of the EuroQol Group’s 5-domain 3 level questionnaire(EQ-5D-3L) was used to interview the CKD patients. At the same time we collected the general messages and clinical laboratory testing results of these patients, then found out the factors that affected the quality of life in patients with CKD using correlation analysis. Results: The visual analogue scale(VAS) scores were consistent with the health description system evaluation results. The VAS scores were negative related to age, Scr, BUN, CysC, p, Ca•P, ferritin and Up/Ucr, while had a positive correlation with eGFR, Hb, Alb and ApoA1. Conclusion: The survey in our center showed that female patients of CKD were more prone to anxiety and depression status. The renal function, anemia and micro inflammation state had significant influence to the quality of patients’ life, which verified that this simple and feasible scale can reflect the health related quality of life of CKD patients in a good way.