目的  探讨口腔健康教育对维持性血液透析患者微炎症的影响。方法80 例患者随机分为治疗组40 例，对照组40 例，治疗组行口腔健康教育3 个月，对照组未行口腔健康教育。观察两组患者口腔健康状况和微炎症状态的变化。结果治疗组经口腔健康教育3 个月后牙龈出血指数(SBI)、菌斑指数(PLI)、牙龈指数(GI)和血清中肿瘤坏死因子α(TNF-α)、高敏C 反应蛋白(hs-CRP)水平均较干预前低[SBI,2.35±0.88 比2.83±0.71(t=2.684,P =0.009);PLI,1.63±0.46 比1.99±0.51(t=3.323,P =0.001); GI,1.49±0.39 比1.88±0.41(t=3.289,P=0.002)；TNF-α,5.72±1.68 ng/L 比6.60±2.01 ng/L(t=2.123,P =0.037);hs- CRP,30.36 ± 9.25 mg/L 比38.12 ± 12.59 mg/L(t=3.141,P =0.002)]，而对照组患者SBI、PLI、GI 的指数和TNF-α、hs- CRP 水平的干预前后的比较无差别(P＞0.05)。结论口腔健康教育可改善维持性血液透析患者微炎症状态，应重视对维持性血液透析患者口腔健康教育。

Objective To explore the effect of oral health education on micro-inflammatory state in maintenance hemodialysis (MHD) patients. Methods Eighty patients were randomly divided into the treatment group (n=40) or the control group (n=40). Oral health education was carried on for 3 months in patients in the treatment group but not in those in the control group. Oral health condition and micro- inflammatory state were then observed in the two groups of MHD patients. Results Gingival bleeding index (SBI), plaque index (PLI), gingival index (GI), and serum TNF- α and hs-CRP decreased in the treatment group after oral health education for 3 months (2.35±0.88 vs. 2.83±0.71, t=2.684, P=0.009 for SBI; 1.63±0.46 vs. 1.99±0.51, t=3.323, P =0.001 for PLI; 1.49±0.39 vs. 1.88±0.41, t=3.289, P =0.002 for GI; 5.72±1.68 ng/L vs. 6.60±2.01 ng/L, t=2.123, P=0.037 for TNF-α; 30.36±9.25 mg/L vs. 38.12±12.59 mg/L, t=3.141, P=0.002 for hs-CRP). These indices were unchanged in the control group (P＞0.05). Conclusion Oral health education could alleviate micro-inflammatory state in MHD patients. Therefore, oral health education should be considered as an important measure in these patients.