【摘要】目的本研究旨在研究腹膜透析患者血清维生素D 水平与肌力之间的相关关系。方法本研究共纳入北京大学第一医院的维持性腹膜透析患者206 例。血25(OH)D 是通过酶联免疫吸附试验测定。肌力用握力计测量优势手握力。并记录人口学资料，合并症和其他临床变量。结果本研究患者平均年龄为56.3±12.5 岁，中位透析龄为33.17(9～52.3)。糖尿病和心脑血管疾病的发生率分别为33%和46.1%。血25(OH)D 的中位数是17.2(12.8～23.9)nmol/L。无论是单变量还是多变量分析(经人口学变量,合并症和疾病相关变量校正后)显示,血25(OH)D 和握力呈正相关。血25(OH)D 高水平组和中等水平组均预测较高的握力。结论在腹膜透析人群中血25(OH)D 水平和肌力正相关。

【Abstract】Objective To investigate the relationship between serum 25(OH)D level and muscle strength in peritoneal dialysis (PD) patients. Method This cross-sectional study included 206 PD patients treated in our nephrology center. Serum 25(OH)D was measured by enzyme- linked immunosorbent assay. Handgrip strength was measured by using an adjustable handheld dynamometer for dominant arm. Demographic data, comorbidity and other clinical variables were also collected. Result The mean age of this cohort was 56.3± 12.5 years. The median of dialysis duration was 33.17 (9～52.3) months. Diabetes and cardiovascular disease was present in 33% and 46.1% of the patients, respectively. The median concentration of serum 25(OH)D was 17.2 (12.8～23.9) nmol/L. Serum 25(OH)D level was positively correlated with handgrip strength after adjustment for demographic data, comorbidity and clinical variables. Patients with middle or higher serum 25(OH) D level were predicted to have higher handgrip strength. Conclusion Serum vitamin D level was positively associated with muscle strength in PD patients.