Objective To assess the clinical application of arteriovenous grafts in lower extremities in end-stage renal disease patients. Methods The clinical data of 11 patients treated with arteriovenous grafts in lower extremities for hemodialysis vascular access in our hospital were analyzed retrospectively. Results All operations were successfully performed, and all of the fistula were used for blood access in hemodialysis after the operation for 4~8 weeks. Primary patency rate was 100%, and the blood flow ranged from 200 ml/ min to 360ml/min. Patients had no postoperative complications such as graft infection during the follow-up period of 3~19 months. Conclusions Lower extremity arteriovenous graft is feasible for end-stage renal disease patients with exhausted arm access sites.