乙型肝炎病毒感染是我国乃至世界范围内的公共问题。乙型肝炎病毒感染的隐匿性，使感染不能及时发现，进而导致疾病的传播。乙型肝炎病毒的检测指标能够间接反映患者体内病毒的感染状态，本文旨在讨论传统检验指标乙型肝炎表面抗原(HBsAg)、表面抗体(抗- HBs)、乙型肝炎e 抗原(HBeAg)、e 抗体(抗-HBe)、乙型肝炎核心抗体(抗-HBc)、乙型肝炎病毒DNA(HBV DNA)以及新的生物学标记物共价闭合环状DNA(cccDNA)、乙型肝炎核心抗原相关抗原(HBcrAg)对乙型肝炎患者体内病毒复制情况的提示意义。

Hepatitis B virus infection is a global public problem. Because of the lack of typical clinical manifestation, occult hepatitis B infection is often unaware by the majority of infected people, leading to spread of the infection. Serological markers of HBV and quantification of HBV DNA can virtually reflect status of hepatitis B virus infection. This article aims to discuss HBsAg and anti-HBs antibody, HBeAg and anti- HBe antibody, anti-HBc antibody, HBV DNA, and newly discovered biological markers for HBV replication in vivo.