【摘要】维生素D 缺乏在慢性肾脏病(chronic kidney disease，CKD)患者中普遍存在，尤其是在尿毒症维持透析患者中，维生素D 缺乏比率高达79%[1]，众多研究表明，CKD 患者补充活性维生素D 不仅可以纠正钙磷代谢异常、预防继发性甲状腺旁腺功能亢进(secondary hyperparathyroidism，SHPT)、改善骨密度，降低骨折风险，还可以降低透析患者心血管疾病的发生风险、参与免疫调节、抑制炎症反应、控制血压、降低尿蛋白等益处。

【Abstract】Vitamin D deficiency is a common complication in patients with chronic kidney disease(CKD). In uremic patients with maintenance dialysis, vitamin D deficiency rate is as high as 79%. Numerous studies have shown that vitamin D supplementation in CKD patients can treat the abnormal calcium and phosphorus metabolism, prevent secondary hyperparathyroidism, improve bone mineral density, reduce the risk of fractures and reduce the risk of cardiovascular disease. Vitamin D supplementation is also useful for immune regulation, inhibition of inflammatory response, blood pressure control, and reducing urinary protein.