【摘要】自噬(autophagy)是细胞降解自身受损、老化的细胞器和大分子物质的过程，在维持细胞的生存，发育和内环境稳定中发挥着至关重要的作用。血管钙化是慢性肾脏病患者普遍存在的并发症，越来越多的研究发现自噬与血管疾病的病理生理进程密切相关。本文就自噬对血管平滑肌细胞及血管钙化的影响进行综述，希望从细胞水平自噬的角度来了解血管钙化的病理机制，从而为治疗慢性肾脏病引起的血管钙化提供新的思路。

【Abstract】Autophagy is a process through which injured and senescent organelles and macromolecular substances in cells are degraded. Autophagy plays a vital role in cell survival, development and homeostasis of interior environment. Vascular calcification is a common complication of chronic kidney disease, and many studies have demonstrated that autophagy is closely related to the pathogenesis of vascular diseases. In this article we comprehensively review the literature about the effects of autophagy on vascular smooth muscle cells and vascular calcification, intending to understand the mechanism of vascular calcification with respect to autophagy and to provide a novel insight into the treatment of chronic kidney disease.