【摘要】目的引进透析患者14 项尿毒症皮肤瘙痒量表(14-item uremic pruritus in dialysis patients scale,14-Item UP-Dial Scale)，翻译成中文版，分析其信效度，评估该量表在我国患者中的适用性。方法将英文版量表进行翻译和回译，确定中文版量表，并在270 例尿毒症皮肤瘙痒患者中进行信效度分析。通过Cronbach α系数、重测信度、各项目与量表总分的相关性分析检验量表信度。使用内容效度指数评价量表内容效度，Pearson 相关分析检验量表效标效度，探索性因子分析检验量表结构效度。结果量表由14 项问题组成，分为症状和体征(瘙痒时间、瘙痒程度、瘙痒部位和面积、皮肤抓痕、麻木感、蚁行感、皮肤干燥)、睡眠(入睡困难、夜间醒来、睡眠质量)和社会心理(工作/学习、社交、情绪、性生活)3 个维度。3 个维度分量表和总量表的Cronbach α系数分别为0.749、0.710、0.845、0.894。3 个维度分量表和总量表的重测信度系数r 分别为0.968、0.951、0.977、0.976(均P＜0.001)。各项目与分量表以及总量表的相关系数r 为0.413～0.892(均P＜0.001)。麻木感和性生活的内容效度指数均为0.83，余各题项的内容效度指数均为1.00。量表的平均内容效度指数为0.98。校标效度r=0.809(P＜0.001)。量表KMO 检验值为0.907，Bartlett 球形检验χ2= 1837.141 (υ=91，P＜0.001)，共提取出3 个公因子，其累积解释方差为61.81%。结论中文版透析患者14 项尿毒症皮肤瘙痒量表具有较好的信度与效度，可作为我国尿毒症皮肤瘙痒患者的测量工具。

【Abstract】Objective To introduce the 14-item uremic pruritus in dialysis patients scale (14-item Updial scale), translate the scale, test the reliability and validity of the scale, and then evaluate its usefulness in Chinese patients. Methods We translated and back-translated the original scale to set up the Chinese version scale. Reliability and validity of the Chinese version scale was examined in 270 dialysis patients with uremic pruritus. Reliability was tested by Cronbach's α coefficient, test- retest reliability, and correlation coefficient between each item and the total score of the scale. Content validity of the scale was evaluated by content validity index (CVI). Criterion related validity was tested by the correlation between the Chinese version scale and the visual analogue scale. Construct validity was tested by exploratory factor analysis. Results The scale is composed of 14 questions, which are divided into 3 dimensions: symptoms and signs (itch duration, itching degree, itching size, lesions from scratching, feel numb, crawling like ants or insects, and dry skin), sleep (difficulty to fall asleep, waking up during the night, interfere sleep quality), and social psychology (work/study, social interaction, mood, and any sexual difficulties). The Cronbach's α of the 3 subscales and the whole scale were 0.749, 0.710, 0.845 and 0.894 respectively. The test-retest reliability coefficients of the 3 subscales and the whole scale were 0.968, 0.951, 0.977 and 0.976 respectively (P<0.001). The correlation coefficients between each item and its dimensional subscale and the whole scale were 0.413～0.892 (P<0.001). The item-level

content validity index (CVI) of item 5 (feel numb) and item 14 (any sexual difficulties) were both 0.83, and the remaining items were all 1.00. The average scale-level CVI was 0.98. Criterion related validity was 0.809 (P＜0.001). KMO test value was 0.907. The spherical Bartlett test obtained χ2=1837.141 (υ =91, P＜0.001). The result of exploratory factor analysis showed that three common factors explained 61.81% of the total variance. Conclusion The Chinese version of 14-item uremic pruritus in dialysis patients scale has good reliability and validity, which can be used to evaluate uremic pruritus in dialysis patients in China.