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专题与讲座

巨噬细胞对腹膜透析相关性腹膜纤维化研究进展

  • 唐寒芬 ,
  • 朱旭萍 ,
  • 刘伏友
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  • 1. 中南大学湘雅二医院肾内科
    2. 中南大学湘雅二医院营养科

收稿日期: 2019-01-22

  修回日期: 2019-05-09

  网络出版日期: 2019-09-02

基金资助

湖南省自然科学基金课题,课题编号为2019JJ50862

Research advances in the function of macrophages in peritoneal dialysis related peritoneal fibrosis

  • TANG Han-Fen ,
  • ZHU Xu-Ping ,
  • LIU Fu-You
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  • 1Institute of Nephrology and 2Department of Nutrition, The Second Xiangya Hospital, Central South University, Changsha 410011, China

Received date: 2019-01-22

  Revised date: 2019-05-09

  Online published: 2019-09-02

摘要

【摘要】腹膜透析是终末期肾病患者的三大替代治疗方法之一。腹膜透析相关性腹膜纤维化是腹膜透析的主要并发症,也是腹膜透析治疗失败的重要原因之一。腹膜透析相关性腹膜纤维化主要发病机制有转化生长因子-β1 表达异常、微小RNA 表达异常以及上皮间质转化等。近年来,研究发现巨噬细胞在腹膜纤维化的发生和发展中发挥着重要的作用。本文主要就巨噬细胞对腹膜透析相关性腹膜纤维化的研究进展进行综述。

本文引用格式

唐寒芬 , 朱旭萍 , 刘伏友 . 巨噬细胞对腹膜透析相关性腹膜纤维化研究进展[J]. 中国血液净化, 2019 , 18(09) : 597 -599 . DOI: 10.3969/j.issn.1671-4091.2019.09.004

Abstract

【Abstract】Peritoneal dialysis (PD) is one of the three effective treatments for end- stage renal failure. However, peritoneal fibrosis is an important complication in PD patients, and is one of the important causes leading to failure of PD. The pathogenesis of peritoneal fibrosis includes abnormal expressions of transforming growth factor- β1 and microRNA, epithelial- mesenchymal transition, etc. Recently, many studies report that macrophages play an important part in the occurrence and development of peritoneal fibrosis. This review focuses on the research advances in macrophage cells in the pathogenesis of PD related peritoneal fibrosis.

参考文献

[1]Jha V, Garcia G G,Iseki K,et al.Chronic kidney disease global dimension and perspectives[J].Lancet, 2013(382): 260-72.
[2]Fang W, Zhi H,Jinwei W,et al.Prevalence and Risk Factors for CKD: A Comparison Between the Adult Populations in China and the United States[J]. Kidney Int Rep, 2018, 3(5): 1135-1143.
[3]Zhang Q L and Rothenbacher D. Prevalence of chronic kidney disease in China: a cross-sectional survey[J]. Lancet, 2012, 379(9818): 815-822.
[4]Caskey F J, Kramer A, Elliott R F, etal.Global variation in renal replacement therapy for end-stage renal disease[J]. Nephrol Dial Transplant, 2011, 26(8): 2604-10.
[5]Levin A,Tonellit M,Bonventre J,et al. Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy[J]. Lancet, 2017, 390(10105): 1888-1917.
[6]Mehrotra R,Devuyst O,Davies SJ, et al.The Current State of Peritoneal Dialysis[J]. J Am Soc Nephrol, 2016,27(11): 3238-3252.
[7]Jain A K , Blake P , Cordy P , et al.Global trends in rates of peritoneal dialysis[J]. J Am Soc Nephrol, 2012,23(3):533-44.
[8]Li K T,Chow K M,Van D L, et al.Changes in the worldwide epidemiology of peritoneal dialysis[J]. Nat Rev Nephrol, 2017,13(2): 90-103.
[9]Liyanage T,Ninomiya T,Jha V,et al.Worldwide access to treatment for end-stage kidney disease a systematic review[J]. Lancet, 2015,385(9981): 1975-1982.
[10]Leung C B, Cheung W Land Li P K. Renal registry in Hong Kong-the first 20 years[J]. Kidney Int Suppl (2011), 2015, 5(1): 33-38.
[11]Yu X and Yang X. Peritoneal dialysis in China: meeting the challenge of chronic kidney failure[J]. Am J Kidney Dis, 2015,65(1): 147-51.
[12]Tang C, Kuo C, Huang K, et al. A Comparative Cost Analysis on Peritoneal Dialysis Versus Hemodialysis in Taiwan[J]. Value in Health, 2016,19(7): A607.
[13]Li K T and Kwong W K. Current Challenges and Opportunities in PD[J]. Semin Nephrol, 2017,37(1): 2-9.
[14]Devuyst O, Margetts P J and Topley N. The pathophysiology of the peritoneal membrane[J]. J Am Soc Nephrol, 2010,21(7): 1077-85.
[15]Chaimovitz, C. Peritoneal dialysis[J]. Kidney International, 1994,45(4): 1226-1240.
[16]Raffaele S,Roberto M V,Cecilia B, et al.Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis[J]. Stem Cells International, 2016,2016: 1-11.
[17]Tomino Y. Mechanisms and interventions in peritoneal fibrosis[J].Clinical & Experimental Nephrology, 2012,16(1): 109-114.
[18]Jaguin M, Noémie Houlbert,Fardel O,et al.Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin[J].Cellular Immunology,2013,281(1):51-61.
[19]Martinez F O, Helming L and Gordon S.Alternative activation of macrophages: an immunologic functional perspective[J].Annu Rev Immunol, 2009, 27(1): 451-483.
[20]Dahdah A, Gautier G, Attout T, et al. Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis[J].J Clin Invest, 2014,124(10): 4577-4589.
[21]Okabe Y and Medzhitov R.Tissue-specific signals control reversible program of localization and functional polarization of macrophages[J].Cell,2014,157(4):832-44.
[22]Nikolic-Paterson D J, Wang S and Lan H Y.Macrophages promote renal fibrosis through direct and indirect mechanisms[J].Kidney Int Suppl,2014. 4(1): 34-38.
[23]Padwal M and Margetts P J. Experimental systems to study the origin of the myofibroblast in peritoneal fibrosis[J].Kidney Res Clin Pract, 2016, 35(3): 133-41.
[24]Lamouille S , Xu J and Derynck R. Molecular mechanisms of epithelial-mesenchymal transition[J]. Nat Rev Mol Cell Biol, 2014,15(3): 178-96.
[25]Zhu L , Fu X ,Chen X ,et al.M2 macrophages induce EMT through the TGF-beta/Smad2 signaling pathway[J]. Cell Biol Int, 2017, 41(9): 960-968.
[26]Pan B,Liu G,Jiang Z,et al.Regulation of renal fibrosis by macrophage polarization[J].Cell Physiol Biochem, 2015,35(3): 1062-9.
[27]Shi J , Li Q , Sheng M X , et al.The Role of TLR4 in M1 Macrophage-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells[J]. Cell Physiol Biochem, 2016,40(6): 1538-1548.
[28]Kariya T, Nishimura H,Mizuno M, et al.TGF-beta1-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis[J]. Am J Physiol Renal Physiol, 2018,314(2): 167-180.
[29]Naiki Y , Maeda Y , Matsuo K , et al.Involvement of TGF-beta signal for peritoneal sclerosing in continuous ambulatory peritoneal dialysis[J].Journal of Nephrology, 2003, 16(1): 95-102.
[30]Zhang Y E. Non-Smad Signaling Pathways of the TGF-β Family[J].Cold Spring Harbor Perspectives in Biology, 2017,9(2).
[31]Jang Y H , Shin H S , Sun Choi H , et al.Effects of dexamethasone on the TGF-β1-induced epithelial-to-mesenchymal transition in human peritoneal mesothelial cells[J]. Laboratory Investigation, 2013, 93(2): 194-206.
[32]Duan W J , Yu X, Huang X R , et al.Opposing roles for smad2 and smad3 in peritoneal fibrosis in vivo and vitro[J]. Am J Pathol, 2014,184(8): 2275-2284.
[33]Graff J W , Dickson A M , Clay G , et al. Identifying functional microRNAs in macrophages with polarized phenotypes[J]. J Biol Chem, 2012, 287(26): 21816-25.
[34]Melisa L A , Timothy B and Jenkins R H.microRNA regulation of peritoneal cavity homeostasis in peritoneal dialysis[J]. Biomed Res Int, 2015, 2015: 1-9.
[35]Ge Y,Xiao L,Chen X, et al.MicroRNAs in peritoneal dialysis effluent are promising biomarkers for peritoneal fibrosis in peritoneal dialysis patients[J]. Med Hypotheses, 2012. 78(1):155-156.
[36]Yu J W ,Duan W J , Huang X R , et al. MicroRNA-29b inhibits peritoneal fibrosis in a mouse model of peritoneal dialysis[J]. Lab Invest, 2014, 94(9): 978-990.
[37]Lopezanton M , Lambie M , Lopezcabrera M ,et al.miR-21 Promotes Fibrogenesis in Peritoneal Dialysis[J]. Am J Pathol, 2017,187(7): 1537-1550.
[38]Zhou Q , Yang M , Lan H Y , et al. miR-30a negatively regulates TGF-beta1-induced epithelial-mesenchymal transition and peritoneal fibrosis by targeting Snai1[J]. Am J Pathol, 2013,183(3): 808-19.
[39]Layoun A ,Samba M and Santos M M. Isolation of murine peritoneal macrophages to carry out gene expression analysis upon Toll-like receptors stimulation[J]. J Vis Exp, 2015(98):e52749
[40]Liao C T , Andrews R , Wallace L E , et al.Peritoneal macrophage heterogeneity is associated with different peritoneal dialysis outcomes[J]. Kidney Int, 2017,91(5): 1088-1103.
[41]Lucendo B . Alternative activation of macrophages in human peritoneum: implications for peritoneal fibrosis[J]. Nephrol Dial Transplant, 2011, 26(9): 2995-3005.
[42]Li Q, Zheng M , Liu Y , et al. A pathogenetic role for M1 macrophages in peritoneal dialysis-associated fibrosis[J]. Mol Immunol, 2018,94:131-139.
[43]Oishi S , Takano R , Tamura S , et al. M2 polarization of murine peritoneal macrophages induces regulatory cytokine production and suppresses T-cell proliferation[J]. Immunology, 2016,149(3): 320-328.
[44]Wang J, Liu J , Wang Y , et al. High glucose induces alternative activation of macrophages via PI3K/Akt signaling pathway[J]. J Recept Signal Transduct Res, 2017,37(4):409-415.
[45]Nakayama M , Zhu W J , Watanabe K , et al. Dissolved molecular hydrogen (H 2 ) in Peritoneal Dialysis (PD) solutions preserves mesothelial cells and peritoneal membrane integrity[J]. BMC Nephrology, 2017,18(1): 327.
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