【摘要】肾性骨营养不良是慢性肾脏病(chronic kindey disease，CKD)患者常见且严重的并发症之一，将增加患者骨折风险和病残率，严重影响其生存质量。骨硬化蛋白(sclerostin)是一种由骨细胞表达的糖蛋白，其能够对骨骼生长代谢的各个阶段产生影响，并且参与了肾性骨营养不良的发病过程，本综述将对骨硬化蛋白在肾性骨营养不良中的研究进展进行探讨。

【Abstract】Renal osteodystrophy is one of the common and serious complications in CKD patients, leading to a significant increase in fracture risk and morbidity and seriously affecting the quality of life. Sclerostin is a glycoprotein expressed by bone cells, affects bone growth and metabolism at all stages, and participates in the pathogenesis of renal osteodystrophy. This review introduces the advances in the study of sclerostin in renal osteodystrophy.