【Abstract】Objective To design a home management manual for renal anemia in order to promote the compliant use of erythropoietin (EPO) and the rate of targeted hemoglobin level in peritoneal dialysis (PD) patients. Methods A total of 100 PD patients regularly followed up in our PD center from January 2017 to December 2017 were enrolled in this study. A professional home management manual for renal anemia was designed according to the rate of targeted hemoglobin level and the status of EPO use. Results The rates of compliant use of EPO (83% vs. 17%) and targeted hemoglobin level (84% vs. 16%) in the 100 PD patients were significantly increased after application of the home management manual for renal anemia for 9 months, as compared with those before the intervention. The rates of compliant use of EPO and targetd hemoglobin level were significantly higher after the intervention for 6 and 9 months than those after the intervention for 3 months (after 6 months: χ2=4.204 and 17.195 respectively, P=0.040 and <0.001 respectively; after 9 months: χ2=4.568 and 6.258 respectively, P=0.033 and 0.012 respectively). Conclusion The home management manual for renal anemia can teach and remined PD patients and their family members to use EPO, and can help medical professionals adjust and follow up the use of EPO in PD patients. This manual is effective in the management of anemia in PD patients and deserves to be widely used clinically.