【Abstract】Objective To investigate the status of motor ability and quality of life in patients with maintenance hemodialysis (MHD) and to analyze the correlation between them. Methods A total of 146 MHD patients treated in West China Hospital of Sichuan University from March to September 2019 were selected as the objects for investigation. Their motor ability (grip strength, 6-minute walk test, balance function test, low back pain disability index) and the present status of quality of life (SF-36) were investigated. The correlation between the two factors was evaluated by Pearson correlation analysis. Results ①Motor ability: The grip strength of dominant hand was 28.14±10.12 kg, while the grip strength of non-dominant hand was 24.78± 8.74 kg(t=-9.669, P＜0.001) in the 146 MHD patients. In 18 cases whose internal fistulas located in the dominant hand, the grip strength of dominant hand was 21.90±5.53 kg, and the grip strength of non- dominant hand 22.41±5.32 kg(t=0.808, P=0.430). The 6-minute walking test was 465.68±85.88 m, the equilibrium test was 53.51 ± 3.92 points, and the lower back pain disability index score was 3.38 ± 3.05; after analyses of these scores we found that 127 patients had mild functional impairment,10 patients had moderate functional impairment, 5 patients had severe functional impairment,and 3 patients had extremely severe functional impairment. ②SF-36 quality of life: The total quality of life score was 61.23～16.29 points, in which emotional functions scored lowest followed by general health and physiological function, and every dimension score was significantly lower than those in general population (t=14.046, 8.241, 5.195, 6.828, 10.286, 2.800, 2.624 and 2.785 respectively; P＜0.001,＜0.001,＜0.001,＜0.001,＜0.001, 0.005, 0.009 and 0.005 respectively). The quality of life score was positively correlated with the 6-minute walking test (r=0.390,P=0.022) and balance function (r=0.269, P=0.001), and negatively correlated with the low back pain disability index (r=- 0.549,P＜0.001).Conclusion Individualized rehabilitation training should be provided for MHD patients with decreased exercise ability and quality of life. Physical ability of MHD patients should be monitored regularly to improve their quality of life.