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综述

维生素D 受体:新发现和临床转化新视角

  • 刘晴晴 ,
  • 李屾森 ,
  • 邓秉权 ,
  • 沈海妍 ,
  • 李汶汶 ,
  • 曹长春
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  • 1南京医科大学附属逸夫医院肾内科

收稿日期: 2020-09-15

  修回日期: 2020-10-20

  网络出版日期: 2021-02-23

基金资助

江苏省基础研究计划(自然科学基金)-青年基金项目(BK20190660);南京医科大学科技发展
基金-一般项目(NMUB2018283);国家自然科学基金资助项目-(81670634)

摘要

【摘要】维生素D 受体(vitamin D receptor,VDR)是目前已知的受维生素D 活性形式——1,25 二羟维生素D3[1,25(OH)2D3]调节的唯一受体,其主要分布在参与钙磷调节的组织中,如肠、骨、肾、甲状旁腺。近期有研究显示,VDR 亦可以表达于免疫细胞及其他细胞类型,通过基因及非基因调控途径参与炎症及免疫相关信号通路的转录调控,这也提示维生素D 除了调节钙磷吸收、参与骨形成、吸收、矿化的经典作用外,还参与调节炎症反应和免疫应答、抑制肿瘤等非经典作用。本文就近年来有关VDR 的新发现及临床转化潜在靶点做相关综述。

本文引用格式

刘晴晴 , 李屾森 , 邓秉权 , 沈海妍 , 李汶汶 , 曹长春 . 维生素D 受体:新发现和临床转化新视角[J]. 中国血液净化, 2021 , 20(02) : 107 -110 . DOI: 10.3969/j.issn.1671-4091.2021.02.008

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