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综述

Klotho 在慢性肾脏病血管钙化中作用的研究进展

  • 杨枫 ,
  • 林评兰 ,
  • 邹赟 ,
  • 叶朝阳
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  • 1上海中医药大学附属曙光医院肾病科,中医肾病研究所,肝肾疾病病证教育部重点实验室(上海中医药大学),上海市中医临床重点实验室(14DZ2273200)

收稿日期: 2020-10-15

  修回日期: 2020-12-09

  网络出版日期: 2021-03-12

基金资助

浦东新区中西医结合慢性肾病学科群(PWZxq2017-07),国家自然科学基金面上项目(81873617),
上海中医药大学预算内项目(18LK046),上海市青年科技英才扬帆计划项目(19YF1449800)

Research progress in the role of klotho in vascular calcification in chronic kidney disease

  • YANG Feng ,
  • LIN Ping-Lan ,
  • ZOU Yun ,
  • YE Chao-Yang
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  • 1Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; Traditional Chinese Medicine Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine; Key Laboratory of Liver and Kidney Diseases, Ministry of Education; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai 201203, China

Received date: 2020-10-15

  Revised date: 2020-12-09

  Online published: 2021-03-12

摘要

慢性肾脏病(Chronic Kidney Disease, CKD)发病率逐年升高,慢性肾脏病患者随其肾功能下降并发骨矿物质代谢紊乱,主要表现为钙磷代谢异常、继发性甲状旁腺功能亢进、血管钙化(Vascular calcification, VC)等,导致心血管病变高发及死亡率增加。研究表明,抗衰老基因Klotho主要表达于肾,具有抑制肾纤维化和调节钙磷代谢紊乱等保护肾脏的作用。本文围绕klotho蛋白在VC中的作用最新研究进展进行综述。

本文引用格式

杨枫 , 林评兰 , 邹赟 , 叶朝阳 . Klotho 在慢性肾脏病血管钙化中作用的研究进展[J]. 中国血液净化, 2021 , 20(03) : 189 -192 . DOI: 10.3969/j.issn.1671-4091.2021.03.010

Abstract

【Abstract】The incidence of chronic kidney disease (CKD) is increasing progressively. CKD patients are frequently accompanied with bone mineral metabolism disorder (CKD-MBD) along with the decline of renal function. CKD-MBD is mainly manifested by abnormal calcium and phosphorus metabolism, secondary hyperparathyroidism and vascular calcification (VC), leading to the higher incidence of cardiovascular disease and the negative impacts on quality of life and prognosis of the patients. Recent studies have shown that Klotho is an anti-aging gene, which is mainly expressed in kidney and protects kidney through the inhibition of renal fibrosis and regulation of calcium and phosphorus metabolism. This review focuses on recent research progress in the role of Klotho on VC.

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