【摘要】目的探讨维生素D 在维持性血液透析患者体力活动和生活质量之间的中介作用。方法采用国际体力活动问卷长版与简明健康状况量表，对92 例维持性血液透析患者进行体力活动与生活质量的调查，同时检测患者25(OH)D3水平。结果体力活动(对数)对生理健康总评的直接效应显著[c’=7.785(5.804,9.766), P＜0.001]，同时也存在以血清25(OH)D3 为中介的间接效应[ab=0.452(0.017, 1.203)]。结论血清25(OH)D3在血液透析患者的体力活动和生活质量(生理健康总评)间起部分中介作用，提高患者血清25(OH)D3水平可能有助于改善患者生活质量。
【Abstract】Objective To explore the mediator effect of vitamin D between physical activity and quality of life in patients undergoing hemodialysis. Methods Physical activity and quality of life in the 94 maintenance hemodialysis patients were measured by the International Physical Activity Questionnaire of Long Version and Brief Health Status Scale. Serum 25(OH)D3 was also measured. Results Both the direct effect of physical activity (logarithm) on physical component summary [C’=7.785 (5.804, 9.766), P<0.001] and the indirect effect through serum 25(OH)D3 [ab=0.452(0.017,1.203)] were significant. Conclusion Vitamin D played as a mediator between physical activity and quality of life. Higher serum 25(OH)D3 level may help improve quality of life in hemodialysis patients.
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