[an error occurred while processing this directive]
综述

局部枸橼酸抗凝在间歇性血液透析中的应用进展

  • 唐小琰 ,
  • 张凌 ,
  • 付平
展开
  • 1四川大学华西医院肾脏内科
    2简阳市人民医院肾脏内科

收稿日期: 2020-12-24

  修回日期: 2021-01-14

  网络出版日期: 2021-06-17

基金资助

四川大学华西医院临床研究孵化项目(2018HXFH018);四川大学华西医院学科卓越发展1.3.5 工程项目(ZYGD18027)

Advances in the application of regional citrate anticoagulation in intermittent hemodialysis

  • TANG Xiao-Yan ,
  • ZHANG Ling ,
  • FU Ping
Expand
  • 1Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, China;  2Department of Nephrology, Jianyang People's Hospital, Chengdu 641400, China

Received date: 2020-12-24

  Revised date: 2021-01-14

  Online published: 2021-06-17

摘要

【摘要】近年来,局部枸橼酸抗凝(regional citrate anticoagulation,RCA)在间歇性血液透析(intermittent hemodialysis,IHD)中使用逐步增多,对于存在出血高危风险及活动性出血的患者有其独特优势,本文回顾分析近年来国内外RCA在IHD 中的应用,为其推广提供参考。

本文引用格式

唐小琰 , 张凌 , 付平 . 局部枸橼酸抗凝在间歇性血液透析中的应用进展[J]. 中国血液净化, 2021 , 20(06) : 387 -390 . DOI: 10.3969/j.issn.1671-4091.2021.06.007

Abstract

【Abstract】In recent years, regional citrate anticoagulation (RCA) has been used increasingly in intermittent hemodialysis due to its unique advantages for patients with high risk of bleeding or active bleeding. In this paper, we review and analyze the application of RCA in intermittent hemodialysis in China and foreign countries in recent years, so as to provide a reference for its popularization.

参考文献

[1]Morita Y, Johnson RW, Dorn RE, et al.Regional anticoagulation during hemodialysis using citrate[J].Am J Med Sci, 1961, Jul(242):32-43
[2]Kidney Disease Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group (2012) .KDIGO Clinical Practice Guideline for Acute Kidney Injury 2012[J].Kidney Int, 2012, -(-):1-138
[3] 陈香美.血液净化标准操作规程(2020版)[J].北京:人民军医出版社, 2020, -(-):---
[4]Bauer E, Derfler K, Joukhadar C, et al.Citrate kinetics in patients receiving long-term hemodialysis therapy[J].Am J Kidney Dis, 2005, 46(5):903-907
[5]Dhondt A, Vanholder R, Tielemans C, et al.Effect of regional citrate anticoagulation on leukopenia,complement activation,and expression of leukocyte surface molecules during hemodialysis with unmodified cellulose membranes[J].Nephron, 2000, 85(4):334-342
[6]Gritters M, Grooteman MP, Schoorl M, et al.Citrate anticoagulation abolishes degranulation of polymorphonuclear cells and platelets and reduces oxidative stress during haemodialysis[J].Nephrol Dial Transplant, 2006, 21(1):153-159
[7]Taki K, Takayama F, Tsuruta Y, et al.Oxidative stress,advanced glycation end product,and coronary artery calcification in hemodialysis patients[J].Kidney Int, 2006, 70(1):218-224
[8]Ahmad S, Callan R, Cole JJ, et al.Dialysate made from dry chemicals using citric acid increases dialysis dose[J].Am J Kidney Dis, 2000, 35(3):493-499
[9]Charney DI, Salmond R.Cardiac arrest after hypertonic citrate anticoagulation for chronic hemodialysis[J].ASAIO Trans., 1990, 36(3):217-219
[10]Lanckohr C, Hahnenkamp K, Boschin M.Continuous renal replacement therapy with regional citrate anticoagulation: do we really know the details?[J].Curr Opin Anaesthesiol, 2013, 26(4):428-437
[11]庄峰, 毕逍, 丁峰.长时间枸橼酸抗凝在维持性血液透析患者中的疗效观察[J].临床肾脏病杂志, 2020, 20(09):740-744
[12]Apsner R, Buchmayer H, Lang T, et al.Simplified citrate anticoagulation for high-flux hemodialysis[J].Am J Kidney Dis, 2001, 38(5):979-987
[13]Buturovic-Ponikvar J, Cerne S, Gubensek J, et al.Regional citrate anticoagulation for hemodialysis: calcium-free vscalcium containing dialysate - a randomized trial.[J].Int J Artif Organs., 2008, 31(5):418-424
[14]Evenepoel P, Maes B, Vanwalleghem J, et al.Regional citrate anticoagulation for hemodialysis using a conventional calcium-containing dialysate[J].Am J Kidney Dis, 2002, 39(2):315-323
[15]Mahmood D, Stegmayr BG.Haemodialysis with Tinzaparin Versus Dialysate Citrate as Anticoagulation[J].Blood Purif, 2018, 46(3):257-263
[16]Lin T, Song L, Huang R, et al.Modified regional citrate anticoagulation is optimal for hemodialysis in patients at high risk of bleeding: a prospective randomized study of three anticoagulation strategies[J].BMC Nephrol, 2019, 20(1):472-472
[17] 叶朝阳, 付文成, 戎殳等.高浓度枸橼酸钠应用于含钙透析液行常规血液透析37例临床分析[J].中国实用内科杂志, 2005, -(04):362-363
[18] 张东亮, 张潘, 张周沧.分段枸橼酸抗凝进行含钙透析液高通量血液透析的临床观察[J].中国血液净化, 2016, -(12):686-690
[19] 杨松涛, 赵娜, 胡军, 等.应用普通含钙透析液局部枸橼酸抗凝血液透析的临床观察[J].中国血液净化, 2017, -(07):474-476
[20]雷丽静, 高菊林, 蒋红莉, 等.高出血风险患者两段法枸橼酸抗凝血液透析的临床观察[J].川北医学院学报, 2019, 34(05):593-596
[21]朱淑华, 樊蓉, 徐斌, 等.简化枸橼酸抗凝无肝素透析的疗效观察[J].肾脏病与透析肾移植杂志, 2017, 26(04):323-327
[22]Kreuzer M, Bonzel KE, Büscher R, et al.Regional citrate anticoagulation is safe in intermittent high-flux haemodialysis treatment of children and adolescents with an increased risk of bleeding[J].Nephrol Dial Transplant, 2010, 25(10):3337-3342
[23] 冉梦晓, 陈辉.局部枸橼酸抗凝对老年终末期肾脏病维持性血液透析患者肾功能、凝血功能及体外循环凝血的影响分析[J].中国医学前沿杂志(电子版), 2019, -(04):49-52
[24]Kiki? Z, Lorenz M, Sunder-Plassmann G, et al.Effect of hemodialysis before transplant surgery on renal allograft function--a pair of randomized controlled trials[J].Transplantation, 2009, 88(12):1377-1385
[25]Patel S, Wendon J.Regional citrate anticoagulation in patients with liver failure--time for a rethink?[J].Crit Care, 2012, 16(5):153-153
[26] Pourcine F, Vong LVP, Chelly J, et al.Sustained low-efficiency dialysis with regional citrate anticoagulation for patients with liver impairment in intensive care unit: A single-center experience.[J].Ther Apher Dial, 2020, -(-):---
[27]Chen C, Ye C.Regional anticoagulation with citrate for maintenance haemodialysis in a patient with liver cirrhosis for 30 months[J].Nephrology (Carlton), 2011, 16(08):786-787
[28]Wexler IB, Pincus JB, Natelson S, et al.The fate of citrate in erythroblastotic infants treated with exchange transfusion[J].J Clin Invest, 1949, 28(3):474-481
[29]Schmitz M, Joannidis M, Czock D, et al.Regional citrate anticoagulation in renal replacement therapy in the intensive care station : Recommendations from the renal section of the DGIIN,?GIAIN and DIVI[J].Med Klin Intensivmed Notfmed, 2018, 113(5):377-383
[30]Buturovi?-Ponikvar J, Pernat AM, Ponikvar R.Citrate anticoagulation during plasma exchange in a patient with thrombotic thrombocytopenic purpura: short heparin-free hemodialysis helps to attenuate citrate load[J].Ther Apher Dial, 2005, 9(3):258-261
[31]Antonic M, Gubensek J, Buturovic-Ponikvar J, et al.Treatment Efficacy and Safety During Plasma Exchange With Citrate Anticoagulation: A Randomized Study of 4 Versus 15% Citrate[J].Artif Organs, 2016, 40(4):368-375
[32]Farah M, Levin A, Kiaii M, et al.Combination hemodialysis and centrifugal therapeutic plasma exchange: 18 years of Canadian experience[J].Hemodial Int, 2013, 17(2):256-265
[33]Ponikvar R, Guben?ek J, Ponikvar JB.Citrate Anticoagulation in Tandem Membrane Plasma-Exchange or Immunoadsorption and Hemodialysis in Patients With Immunological Diseases and Dialysis-Dependence[J].Ther Apher Dial., 2016, 20(3):246-250
[34]Potier J, Dolley-Hitze T, Hamel D, et al.Long-term effects of citric acid-based bicarbonate haemodialysis on patient outcomes: a survival propensity score-matched study in western France[J].Nephrol Dial Transplant, 2020, 35(7):1228-1236
[35] Gabutti L, Lucchini B, Marone C, et al.Citrate- vs. acetate-based dialysate in bicarbonate haemodialysis: consequences on haemodynamics, coagulation, acid-base status, and electrolytes[J].BMC Nephrol, 2009, -(10):7-7
[36]Martin KJ, González EA.Strategies to minimize bone disease in renal failure[J].Am J Kidney Dis, 2001, 38(6):1430-1436
[37] Kuragano T, Furuta M, Yahiro M, et al.Acetate free citrate-containing dialysate increase intact-PTH and BAP levels in the patients with low intact-PTH[J].BMC Nephrol, 2013, -(14):18-18
[38]Apsner R, Gruber D, H?rl WH, et al.Parathyroid hormone secretion during citrate anticoagulated hemodialysis in acutely ill maintenance hemodialysis patients[J].Anesth Analg, 2004, 99(4):1199-1204
文章导航

/

[an error occurred while processing this directive]