【摘要】目的研究维持性血液透析(maintenance hemodialysis，MHD)相关肌肉减少症(sarcopenia，简称肌少症)的患病率及危险因素。方法入选359 例MHD 患者，收集患者相关资料测量肌肉质量、力量及肌肉功能，将研究对象分成肌少症组和非肌少症组，分析肌少症的患病率及危险因素。结果本研究纳入359 名MHD 患者，肌少症83 例，非肌少症276 例，肌少症患病率为23.1%。多因素Logistic 回归分析显示年龄(OR=1.962,95%CI：1.264～3.044,P =0.003)、营养不良(OR=2.697,95% CI：1.283～5.669, P=0.009)及抑郁(OR=1.707,95% CI：1.116～2.611,P =0.014)是肌少症的独立危险因素，体质量指数 (BMI)是肌少症的保护因素(OR=0.040, 95% CI：0.015～0.108,P＜0.001)。结论MHD 肌少症患病率高达23.1%，年龄、营养不良、抑郁是其独立危险因素，BMI是其保护性因素。
【Abstract】Objective To study the prevalence and risk factors of maintenance hemodialysis (MHD)-associated sarcopenia. Methods A total of 359 MHD patients were enrolled in this study. Clinical data of the patients were collected. Muscle mass, strength and muscle function were tested. Subjects were divided into sarcopenia group and non-sarcopenia group, and the prevalence and risk factors of sarcopenia were then analyzed. Results The 359 MHD patients were divided into the sarcopenia group (n=83) and the non-sarcopenia group (n=276). The prevalence of MHD-associated sarcopenia in the patients was 23.1%. Multivariate logistic regression analysis showed that age (OR=1.962, 95% CI=1.264~3.044, P=0.003), malnutrition (OR=2.697,
95% CI=1.283~5.669, P=0.009) and depression (OR=1.707, 95% CI=1.116~2.611, P=0.014) were the independent risk factors for sarcopenia, and BMI (OR=0.040, 95% CI=0.015~0.108, P＜0.001) was a protective factor for sarcopenia. Conclusion The prevalence of MHD-associated sarcopenia was 23.1%. Age, malnutrition and depression were the independent risk factors for sarcopenia, and BMI was a protective factor for sarcopenia.
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