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维持性血液透析患者动脉钙化与维生素K 关系的研究进展

  • 黎杨梦琦 ,
  • 李英
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  • 1河北医科大学第三医院肾内科

收稿日期: 2021-06-07

  修回日期: 2021-06-30

  网络出版日期: 2021-10-12

Recent advances in the relationship between arterial calcification and vitamin k in maintenance hemodialysis patients

  • LI Yang-MengQi ,
  • LI Ying
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  • 1Department of Nephrology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China

Received date: 2021-06-07

  Revised date: 2021-06-30

  Online published: 2021-10-12

摘要

【摘要】维持性血液透析患者中普遍存在动脉钙化现象,动脉钙化的发生与心血管事件的发生密切相关。基质γ-羧基谷氨酸蛋白(matrix γ-carboxyglutamate protein,MGP)作为一种维生素K 依赖蛋白,可以通过多途径抑制动脉钙化的进展。研究证实,去磷酸化、未羧化基质γ-羧基谷氨酸蛋白(dephosphorylated-uncarboxylated matrix γ-carboxyglutamate protein,dp-ucMGP)作为一类无活性MGP,与维持性血液透析患者死亡风险相关。维生素K 作为维生素K 依赖蛋白(vitamin K-dependent proteins,VKDPs)活化的重要底物,决定了循环VKDP 水平。在维持性血液透析患者中,补充维生素K 可以显著降低去磷酸化、未羧化基质γ-羧基谷氨酸蛋白水平,但尚缺乏相关前瞻性研究明确存在动脉钙化的维持性血液透析患者是否可以从补充维生素K中获益。

本文引用格式

黎杨梦琦 , 李英 . 维持性血液透析患者动脉钙化与维生素K 关系的研究进展[J]. 中国血液净化, 2021 , 20(10) : 657 -660 . DOI: 10.3969/j.issn.1671-4091.2021.10.003

Abstract

【Abstract】The incidence of arterial calcification is higher in maintenance hemodialysis (MHD) patients with chronic kidney disease. Arterial calcification is closely related to the cardiovascular events in these patients. Matrix γ-carboxyglutamate protein (MGP) is a vitamin K dependent protein, which inhibits the progression of arterial calcification through multiple pathways. Studies have confirmed that dephosphorylated and uncarboxylated MGP (dp-ucMGP) is a type of inactive MGP, which is related to the risk of death in MHD patients. Vitamin K is an important substrate for the activation of vitamin K dependent proteins (VKDPs), and
determines the level of circulating VKDPs. Vitamin K supplementation for MHD patients can significantly reduce the level of dp-ucMGP. However, prospective studies providing confirmed data that MHD patients with arterial calcification benefited from vitamin K supplementation are yet insufficient.

参考文献

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