【摘要】慢性肾脏病(chronic kidney disease,CKD)患者清除体内尿毒症毒素能力较正常人明显减退，导致尿毒症毒素的蓄积，从而造成包括心血管系统在内的多个系统受损。血液净化能够通过弥散、对流、吸附等原理清除大部分尿毒症毒素，但由于蛋白结合毒素游离部分较低，常规血液透析难以清除而影响患者预后。本文将主要从CKD 人群中的蛋白结合毒素与心血管疾病进展及血液净化方式对蛋白结合毒素清除效果2方面进行综述。

【Abstract】The clearance capacity of uremic toxin is severely impaired in patients with chronic kidney disease (CKD) than that in normal people. With the accumulation of uremic toxins, many systems including the cardiovascular system are damaged in CKD patients. Blood purification can remove most uremic toxins through diffusion, convection and adsorption. However, the removal rates for protein binding toxins are limited, which affects the prognosis of CKD patients. In this paper, we reviewed the progress of protein binding toxins and cardiovascular disease in CKD patients, and the clearance of protein binding toxins by blood purification.
In this paper, we reviewed the relationship between protein binding toxins and the progress of cardiovascular disease in CKD patients, and the effect of blood purification methods on the removal of protein bining toxins.