【摘要】血清钙蛋白颗粒(calciproteinparticles,CPPs)是一种胶体纳米颗粒，是新近发现的一种慢性肾脏病矿物质和骨代谢异常(chronic kidney disease-mineral and bone disorder,CKD-MBD)的生物标志物,其在慢性肾脏病血管钙化(vascular calcification,VC)中的作用越来越受到人们的重视。本文主要就CPPs 的基本结构及其生物学活性，CPPs 与血管钙化的密切关系做一综述，为慢性肾脏病血管钙化防治提供新的诊断标记物和治疗靶点。

【Abstract】Serum calciprotein particles (CPPs) are present in the form of colloidal nanoparticles in serum and have become a novel biological marker for chronic kidney disease-mineral and bone disorder (CKDMBD). CPPS are now intrigued by its involvement in the pathogenesis of vascular calcification in CKD patients. This article reviews the basic structure and biological activities of CPPs as well as the relationship between CPPs and vascular calcification, so as to provide a new diagnostic marker and therapeutic target for vascular calcification in CKD patients.