【摘要】治疗性血浆置换(therapeutic plasma exchange,TPE)通过分离并清除血浆中可溶的治病物质，并以置换液补充体液、电解质和血浆成分，从而达到治疗的目的。妊娠期出现红细胞同种免疫(red cell alloimmunization, RCA)、血栓性微血管病(thrombotic microangiopathy, TMA)、自身免疫性疾病、脂代谢疾病时，需要考虑应用TPE 治疗，本文对妊娠期进行TPE 治疗的指征、并发症等进行文献综述，供临床实践参考。

【Abstract】Therapeutic plasma exchange (TPE) achieves the treatment purpose by separating and removing the soluble pathogenic substances in plasma and supplementing fluid, electrolytes, plasma components by replacement fluid. Red cell alloimmunization, thrombotic microangiopathy, autoimmune diseases, and lipids disorders in pregnant women are the indications considered to use TPE. The present article reviews the indications and side effects of TPE, in order to provide references useful for clinical practice of this therapeutic method.