目的了解维持性腹膜透析患者红细胞寿命的情况，探讨红细胞寿命的影响因素，为合理治疗提供依据。方法选择2021年6月～8月期间在北京大学人民医院肾内科规律随访、病情稳定、透析3个月以上的腹膜透析患者，采用一氧化碳(CO)呼气法检测红细胞寿命。记录其一般资料、贫血相关指标及其治疗情况。应用SPSS22.0进行统计分析，应用多元线性回归分析红细胞寿命的影响因素。结果①共纳入32例腹膜透析患者，其中男性17例(占53.12%)，年龄(57.42±11.03)岁，透析龄34.00(20.25，104.25)月，原发病以慢性肾小球肾炎居首位，占46.87%。②腹膜透析患者的红细胞寿命44～132天，平均(79.45±24.98)天。③多元线性回归结果显示，血清白蛋白(β=3.269，P=0.010)、血肌酐(β=0.045，P=0.037)以及有无糖尿病(β=-19.702，P=0.041)是红细胞寿命的独立影响因素。结论腹膜透析患者血清白蛋白低、血肌酐低以及合并糖尿病与红细胞寿命缩短独立相关，应针对性地予以治疗。【关键词】腹膜透析；慢性肾脏病；肾性贫血；红细胞寿命
Objective To study red blood cell (RBC) lifespan in patients with maintenance peritoneal dialysis (PD) and to explore the related factors of RBC lifespan, so as to provide the evidences for a rational treatment. Methods The PD patients with stable status and regularly followed up for at least 3 months in the Department of Nephrology, Peking University People’s Hospital from June to August, 2021 were enrolled in this study. RBC lifespan was determined by CO breath test. Their general data, laboratory results, anemia index and anemia treatment were recorded. SPSS 22.0 software was used for statistical analysis. Multivariate linear regression was used to analyze the related factors for RBC lifespan. Results ①A total of 32 PD patients (17 males and 15 females, with a mean age of 57.42±11.03 years) were enrolled in this study. The average PD duration was 34.0 (20.25, 104.25) months. The major primary disease was chronic glomerulonephritis, accounting for 46.9% of the PD patients. ②The RBC lifespan of PD patients ranged from 44 days to132 days, with an average of 79.45±24.98 days. ③Multivariate linear regression analysis demonstrated that serum albumin (β=3.269, P=0.010), serum creatinine (β=0.045, P=0.037), and the presence of diabetes (β=-19.702, P=0.041) were the independent factors relating to RBC lifespan. Conclusion The shortened RBC lifespan in PD patients is independently related to low serum albumin, low serum creatinine level and diabetes mellitus. Treatment aimed at these factors are required.
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