尿毒症毒素与慢性肾脏病肌少症的关系研究进展

方吕贵

doi:10.3969/j.issn.1671-4091.2022.07.013

中国血液净化 >

2022 , Vol. 21 >Issue 07: 521 - 524

DOI: https://doi.org/10.3969/j.issn.1671-4091.2022.07.013

综述

尿毒症毒素与慢性肾脏病肌少症的关系研究进展

方吕贵

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102600 北京，1 中国中医科学院广安门医院南区肾病科
100029 北京，2北京中医药大学研究生院
100700 北京，3中国中医科学院研究生院
100053 北京，4中国中医科学院广安门医院肾病科

收稿日期: 2021-12-23

修回日期: 2022-03-29

网络出版日期: 2022-07-12

基金资助

广安门医院南区院级基金

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Research progress in the relationship between uremic toxins and sarcopenia in chronic kidney disease patients

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Department of Nephrology, South District of Guang-An-Men Hospital, China Academy of Chinese Medical Sciences, Beijing 102600, China; Graduate School of Beijing University of Chinese Medicine, Beijing 100029, China; Graduate School of
China Academy of Chinese Medical Sciences, Beijing 100700, China; Department of Nephrology, Guang-AnMen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

Received date: 2021-12-23

Revised date: 2022-03-29

Online published: 2022-07-12

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摘要

慢性肾脏病(chronic kidney disease，CKD)肌少症有多种病因，尿毒症毒素是其病因之一，
且是CKD肌少症有别于其他肌少症的因素。对尿毒症毒素影响肌少症的文献进行汇总分析，一方面了解
其发病机制，另一方面为CKD肌少症的治疗提供一定的参考。文章侧重对尿毒症毒素与CKD肌少症关系
的研究进展进行综述，试图阐述从毒素清除方面治疗CKD肌少症也是非常有意义的研究方向，可能会发
现治疗CKD肌少症的新策略

关键词： 尿毒症毒素; 肌少症; 综述

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方吕贵 . 尿毒症毒素与慢性肾脏病肌少症的关系研究进展[J]. 中国血液净化, 2022 , 21(07) : 521 -524 . DOI: 10.3969/j.issn.1671-4091.2022.07.013

Abstract

Sarcopenia in chronic kidney disease patients is caused by many factors, of which one is the
uremic toxins, which distinguishes CKD sarcopenia from other sarcopenias. We have reviewed and analyzed
the literature about the effect of uremic toxins on sarcopenia in order to comprehend the pathogenesis of sarcopenia and to find out the references for the treatment strategies of sarcopenia in CKD patients. Here we summarized the recent progresses in the relationship between uremic toxins and CKD sarcopenia, in an attempt to
explore a meaningful research subject and a novel strategy for the treatment of CKD sarcopenia by removal of
uremic toxins.

Key words： Uremic toxin; Sarcopenia; Review

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