钙化防御、钙化性尿毒症性细动脉病或是其他

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doi:10.3969/j.issn.1671-4091.2022.09.001

中国血液净化 >

2022 , Vol. 21 >Issue 09: 625 - 627

DOI: https://doi.org/10.3969/j.issn.1671-4091.2022.09.001

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钙化防御、钙化性尿毒症性细动脉病或是其他

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100044 北京，北京大学人民医院肾内科

收稿日期: 2022-06-07

修回日期: 2022-06-14

网络出版日期: 2022-09-06

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Calciphylaxis, calcific uremic arteriolopathy or others

ZUO Li

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Department of Nephrology, Peking University People’s Hospital, Beijing 100044, China

Received date: 2022-06-07

Revised date: 2022-06-14

Online published: 2022-09-06

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摘要

肾科医师常用钙化防御这个词来描述尿毒症患者出现的一种皮肤干性坏死性的病变，并认为钙化防御的底层机制是小动脉平滑肌细胞向成骨样细胞的主动转分化并引起小动脉中层钙化、血栓形成、小动脉闭塞。但钙化防御这个词在被创造出来时，跟小动脉中层钙化没有关系。这个含义的钙化防御也可出现于非尿毒症患者；而且，慢性肾脏病的动脉中层钙化并不只出现于皮肤细动脉，在脏器外动脉也十分常见。这样，钙化性尿毒症性细动脉病的命名似乎也不合适。那么应该使用什么样的名词来代表这种病变呢？

关键词： ; ">钙化防御；钙化性尿毒症性细动脉病；慢性肾脏病; ">

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左力 . 钙化防御、钙化性尿毒症性细动脉病或是其他[J]. 中国血液净化, 2022 , 21(09) : 625 -627 . DOI: 10.3969/j.issn.1671-4091.2022.09.001

Abstract

Calciphylaxis is often used by nephrologist to describe a kind of painful skin dry gangrene in
some uremic patients. The underlining mechanisms of the skin gangrene is attributed to arterial smooth muscle cells active transformation to osteoblast-like cells, and medium layer calcification, lumen thrombosis and obstruction followed. But when the word calciphylaxis created, it had nothing to do with arterial medium layer calcification. It then was renamed as calcific uremic arteriolopathy. But, calciphylaxis, with the above-mentioned meaning, can also occurred in patients without uremia; never the less, it can also be detected in larger arteries outside organs. It seems now that calcific uremic arteriolopathy is also not a proper name for this condition. Then, what is the proper name for this skin change with medium layer calcification as underlining
mechanism?

Key words： ; ">Calciphylaxis; ">；; ">Calcificuremicarteriolopathy; ">；; ">Chronickidneydisease; ">

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