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综述

Klotho蛋白在移植急性肾损伤中的研究进展

  • 胡微薇 ,
  • 张文君 ,
  • 周小春 ,
  • 王俭勤
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  • 730030 兰州,1兰州大学第二医院肾内科 2甘肃省临床医学研究中心

收稿日期: 2022-03-21

  修回日期: 2022-07-14

  网络出版日期: 2022-10-12

Advances in the study of Klotho protein in acute transplanted kidney injury 

  • HU Wei-Wei ,
  • ZHANG Wen-Jun ,
  • ZHOU Xiao-Chun ,
  • WANG Jian-Qin
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  • Department of Nephrology, Lanzhou University Second Hospital,  2Gansu Provincial Clinical Medical Research Center, Lanzhou 730030, China;

Received date: 2022-03-21

  Revised date: 2022-07-14

  Online published: 2022-10-12

摘要

急性肾损伤(acute kidney injury,AKI)是肾移植的首要并发症,与肾移植的存活率成反比,缺血再灌注损伤是引起肾移植后急性肾损伤的最常见原因。长期以来,供体器官短缺一直是移植手术的一个障碍,越来越多的边缘供体被临床使用,AKI在肾移植中的发病率逐年升高,肾移植的长期结果不尽人意,人们一直在寻求延长移植肾存活率的干预措施。Klotho基因作为一种主要在肾脏中表达的抗衰老基因,其编码的Klotho蛋白是一种多效性蛋白,可能通过多种机制保护肾脏免受缺血性损伤。近年来关于Klotho蛋白与AKI的相关研究很多,然而关于Klotho在肾移植中的数据很少,Klotho在同种异体肾移植中是否起到保护作用仍然是一个有争议的问题,未来需要进一步的研究来阐明Klotho在肾移植领域的复杂机制及其对肾移植结果的影响,以期为改善异体肾脏移植损伤提供新的思路。

本文引用格式

胡微薇 , 张文君 , 周小春 , 王俭勤 . Klotho蛋白在移植急性肾损伤中的研究进展[J]. 中国血液净化, 2022 , 21(10) : 758 -761 . DOI: 10.3969/j.issn.1671-4091.2022.10.012

Abstract

Acute kidney injury (AKI) is a primary complication of renal transplantation and is reversely proportional to the survival rate of renal transplantation. Ischemia-reperfusion injury after renal transplantation is the most important cause of AKI. Due to the shortage of donors, the use of aging kidneys from expanded criteria donors became increased and the incidence of AKI in kidney transplantation is increasing year by year, resulting in the lower rate of long-term survival of transplanted kidney. Many intervention measures to increase the survival rate of transplanted kidney have been tested so far. Klotho protein is a pleiotropic protein expressed in kidney, functions as an anti-aging factor, and may protect the kidney from ischemic injury through multiple mechanisms. Studies about the relationship between Klotho protein and AKI are present in recent years, while studies about Klotho protein relating to renal transplantation are scarce. Whether Klotho protein plays a protective role in allogeneic renal transplantation remains controversial. Studies on the roles of Klotho protein in renal transplantation and its impact on outcomes of renal transplantation are required, to explore an alternative way for the prevention of AKI in allogeneic renal transplantation.

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