参与CKD-MBD的新因子

郭歆; 方敬爱; 王蕊花; 张晓东; 刘文媛; 常沁涛

doi:10.3969/j.issn.1671-4091.2023.01.010

中国血液净化 >

2023 , Vol. 22 >Issue 1: 44 - 47

DOI: https://doi.org/10.3969/j.issn.1671-4091.2023.01.010

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参与CKD-MBD的新因子

郭歆 ,
方敬爱 ,
王蕊花 ,
张晓东 ,
刘文媛 ,
常沁涛

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030001 太原，1山西医科大学第一临床医学院 030001 太原，2山西医科大学第一附属医院肾内科

收稿日期: 2022-06-06

修回日期: 2022-08-12

网络出版日期: 2023-01-12

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Novel factors involved in chronic kidney disease-mineral and bone disorder (CKD-MBD)

GUO Xin ,
FANG Jing-Ai ,
WANG Rui-Hua ,
ZHANG Xiao-Dong ,
LIU Wen-Yuan ,
CHANG Qin-Tao

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First Clinical College, Shanxi Medical University, Taiyuan 030001,China; 2Department of Nephrology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China

Received date: 2022-06-06

Revised date: 2022-08-12

Online published: 2023-01-12

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摘要

多种生物因子参与着慢性肾脏病矿物质和骨代谢异常(chronic kidney disease –mineral and bone disorder，CKD-MBD)的发生发展。除了经典的甲状旁腺激素(PTH)/维生素D轴理论，最近有研究发现成纤维细胞生长因子23(fibroblast growth factor23，FGF23)/Klotho、牙基质蛋白1(dentin matrix protein 1,DMP1)、分泌型蛋白Dickkopf-1(secretory protein Dickkopf 1，DKK1)和硬化蛋白(sclerostin)等因子也直接或间接参与着CKD-MBD的进展。本文将对上述因子的最新研究做一综述。

关键词： 慢性肾脏病矿物质和骨代谢异常; 成纤维细胞生长因子23/Klotho; 分泌型蛋白Dickkopf-1; 硬化蛋白; 牙基质蛋白1

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郭歆 , 方敬爱 , 王蕊花 , 张晓东 , 刘文媛 , 常沁涛 . 参与CKD-MBD的新因子[J]. 中国血液净化, 2023 , 22(1) : 44 -47 . DOI: 10.3969/j.issn.1671-4091.2023.01.010

Abstract

Many biological factors are involved in the occurrence and development of chronic kidney disease-mineral and bone disorder (CKD-MBD). In addition to the classic parathyroid hormone (PTH)/vitamin D axis theory, recent studies have found that fibroblast growth factor 23, FGF23/Klotho, dentin matrix protein 1 (DMP1), secretory protein DicKKOPF-1 (DKK1) and sclerostin are also directly or indirectly involved in the progression of CKD-MBD. This paper reviews the latest research on these factors.

Key words： Chronic kidney disease-mineral and bone disorder; ; Fibroblast growth factor 23/Klotho; DKK1; Sclerostin; Dentin matrix protein1

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