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综述

钙卫蛋白作为腹膜透析相关腹膜纤维化诊疗新靶点的探讨

  • 阮怡霖 ,
  • 徐天 ,
  • 任红
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  • 200025 上海,1上海交通大学医学院附属瑞金医院肾内科

收稿日期: 2022-06-13

  修回日期: 2022-08-21

  网络出版日期: 2023-01-12

Investigation on calprotectin as a new target for the diagnosis and treatment of peritoneal dialyis-related peritoneal fibrosis

  • RUAN Yi-Lin ,
  • XU Tian ,
  • REN Hong
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  • Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2022-06-13

  Revised date: 2022-08-21

  Online published: 2023-01-12

摘要

钙卫蛋白(S100A8/A9)属于S100家族中的Ca2+结合蛋白,具有广泛的生物学活性,可以作为多种疾病的生物标志物。腹膜透析(peritoneal dialysis,PD)相关性腹膜纤维化(peritoneal fibrosis,PF)是PD患者中常见的并发症之一。近年来,S100A8/A9致纤维化作用也逐渐被证实,前期研究证明S100A8/A9在PF时显著上调,抑制PF后表达下降。本文主要围绕S100A8/A9作为PF诊疗新靶点的前景探讨。

本文引用格式

阮怡霖 , 徐天 , 任红 . 钙卫蛋白作为腹膜透析相关腹膜纤维化诊疗新靶点的探讨[J]. 中国血液净化, 2023 , 22(1) : 52 -55 . DOI: 10.3969/j.issn.1671-4091.2023.01.012

Abstract

Calprotectin (S100A8/A9) is a Ca2+ binding protein in the S100 protein family, having a wide range of biological activities and serving as a biomarker for many diseases. Peritoneal dialysis-related peritoneal fibrosis is one of the common complications in peritoneal dialysis (PD) patients. Many studies have recently proved that S100A8/A9 plays an important part in the development of peritoneal fibrosis. Our previous study also confirms that S100A8/A9 is up-regulated in peritoneal fibrosis and down-regulated after inhibition of peritoneal fibrosis. This article discusses the prospect of S100A8/A9 as a new target for the diagnosis and treatment of peritoneal fibrosis.

参考文献

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