我国有巨大的肾性贫血及肿瘤放化疗贫血患病人群。长效红细胞生成素(erythropoietin,EPO)具有半衰期长、生物活性高等优势，能降低给药频率和剂量，提高患者依从性、改善贫血治疗效果。本文就长效EPO的设计方案、优势及应用前景进行综述，旨在为促进长效EPO在国内广泛应用提供理论依据。

China has a large number of patients with renal anemia and tumor anemia after radiotherapy and chemotherapy. Long acting erythropoietin (EPO) has the advantages of long half-life and high biological activity. It can reduce the frequency and dose of administration, improve patient compliance and improve the effect of anemia treatment. This paper summarizes the design scheme, advantages and application prospects of long-acting EPO in order to provide a theoretical basis for promoting the wide application of long-acting EPO in China.