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综述

中性pH-低葡萄糖降解产物腹膜透析液临床应用进展

  • 吴海珊 ,
  • 毛海萍 ,
  • 陈崴 ,
  • 阳晓
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  • 510080 广州,1中山大学附属第一医院肾内科  2卫健委和广东省重点实验室

收稿日期: 2022-12-08

  修回日期: 2022-12-22

  网络出版日期: 2023-04-12

Research progresses in the pH-neutral, low-glucose degradation product dialysates for peritoneal dialysis 

  • WU Hai-Shan ,
  • MAO Hai-Ping ,
  • CHEN Wei ,
  • YANG Xiao
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  • Department of Nephrology, the First Affiliated Hospital, Sun Yat-sen University; 2Key Laboratory of Nephrology, Ministry of Health, Guangzhou 510080, China

Received date: 2022-12-08

  Revised date: 2022-12-22

  Online published: 2023-04-12

摘要

传统腹膜透析液的高浓度葡萄糖、高葡萄糖降解产物、高糖基化终产物、低pH值等生物不相容性是影响腹膜透析(peritoneal dialysis,PD)疗效、导致PD技术失败的主要原因。中性pH-低葡萄糖降解产物(glucose degradation products,GDP)透析液是一种生物相容性透析液,有研究表明中性pH-低葡萄糖降解产物对终末期肾病患者的影响优于传统腹膜透析液,特别对于长透析患者。因此,本文就中性pH-低GDP腹膜透析液对终末期肾病腹膜透析患者残余肾功能、腹膜功能、腹膜炎发生率、患者生存及技术生存、腹膜结构等方面影响的研究进展进行综述。

本文引用格式

吴海珊 , 毛海萍 , 陈崴 , 阳晓 . 中性pH-低葡萄糖降解产物腹膜透析液临床应用进展[J]. 中国血液净化, 2023 , 22(04) : 292 -295 . DOI: 10.3969/j.issn.1671-4091.2023.04.010

Abstract

Conventional glucose-based peritoneal dialysates with higher glucose concentrations, high glucose degradation products, advanced glycation end products and lower pH have been recognized as bio-incompatible, affecting peritoneal dialysis efficacy and leading to technique failure. pH-neutral, low-glucose degradation product dialysates are relatively biocompatible, and are thought to be superior to the conventional dialysates especially in long-term use of peritoneal dialysis. In this paper, we review the recent advances in pH-neutral, low-glucose degradation product dialysates on the residual renal function, peritoneal function, peritonitis rate, patient and technique survival, and peritoneum pathology in peritoneal dialysis patients.

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