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综述

间充质干细胞延缓腹膜纤维化的研究进展

  • 张庆茹 ,
  • 刘晓雨 ,
  • 卢雪红
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  • 130041 长春,1吉林大学第二医院肾病内科

收稿日期: 2023-04-07

  修回日期: 2023-07-01

  网络出版日期: 2023-09-12

Research progresses in mesenchymal stem cells to delay peritoneal fibrosis

  • ZHANG Qing-Ru ,
  • LIU Xiao-Yu ,
  • LU Xue-Hong
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  • Department of Nephrology, The Second Hospital, Jilin University, Changchun 130041, China

Received date: 2023-04-07

  Revised date: 2023-07-01

  Online published: 2023-09-12

摘要

腹膜透析(peritoneal dialysis,PD)作为肾脏替代治疗方式之一,在终末期肾衰竭患者的治疗中占有不可替代的地位。然而,长期的腹膜透析会影响腹膜的功能和结构。腹膜纤维化(peritoneal fibrosis,PF)是长期腹膜透析患者的严重并发症,可导致超滤失败(ultrafiltration failure,UFF)和腹膜透析的中断。近年来,间充质干细胞(mesenchymal stromal cells,MSCs)因其多向分化潜能、免疫调节和组织修复作用成为一个具有临床应用潜力的创新科学研究领域。最近研究表明间充质干细胞可以通过调节炎症、修复损伤以及抑制腹膜间皮细胞的上皮-间充质转化(epithelial-to-mesenchymal transition,EMT)来改善腹膜纤维化。本文就间充质干细胞延缓腹膜纤维化的机制、相关研究和存在的问题等方面进行综述。

本文引用格式

张庆茹 , 刘晓雨 , 卢雪红 . 间充质干细胞延缓腹膜纤维化的研究进展[J]. 中国血液净化, 2023 , 22(09) : 690 -694 . DOI: 10.3969/j.issn.1671-4091.2023.09.012

Abstract

Peritoneal dialysis (PD) is one of the kidney replacement treatments and plays an irreplaceable role in the treatment of end-stage renal failure patients. However, long-term PD can affect the function and structure of the peritoneum. Peritoneal fibrosis is a serious complication in long-term PD patients, leading to ultrafiltration failure and interruption of PD. In recent years, mesenchymal stem cells (MSCs) have become an innovative research field with clinical application potential due to their multi-directional differentiation potential, immunomodulatory and tissue repair abilities. Recent studies have shown that MSCs can ameliorate peritoneal fibrosis by regulating inflammation, repairing damage, and inhibiting epithelial-mesenchymal transformation (EMT) of the peritoneal mesenchymal cells. This article reviews the mechanism, research progresses and difficulties of MSCs used for delaying peritoneal fibrosis.

参考文献

[1] MUZAALE A D, MASSIE A B, WANG M C, et al. Risk of end-stage renal disease following live kidney donation [J]. JAMA, 2014, 311(6): 579-86.
[2] ORTIZ A, COVIC A, FLISER D, et al. Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure [J]. Lancet, 2014, 383(9931): 1831-43.
[3] LI P K, CHOW K M, VAN DE LUIJTGAARDEN M W, et al. Changes in the worldwide epidemiology of peritoneal dialysis [J]. Nat Rev Nephrol, 2017, 13(2): 90-103.
[4] JAIN A K, BLAKE P, CORDY P, et al. Global trends in rates of peritoneal dialysis [J]. J Am Soc Nephrol, 2012, 23(3): 533-44.
[5] SMIT W, PARIKOVA A, KREDIET R T. Ultrafiltration failure in peritoneal dialysis. Causes and clinical consequences [J]. Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 2005, 57(3): 165-74.
[6] WILLIAMS J D, CRAIG K J, TOPLEY N, et al. Morphologic Changes in the Peritoneal Membrane of Patients with Renal Disease [J]. Journal of the American Society of Nephrology, 2002, 13(2): 470-9.
[7] ZHOU Q, BAJO M A, DEL PESO G, et al. Preventing peritoneal membrane fibrosis in peritoneal dialysis patients [J]. Kidney Int, 2016, 90(3): 515-24.
[8] PITTENGER M F, MACKAY A M, BECK S C, et al. Multilineage potential of adult human mesenchymal stem cells [J]. Science, 1999, 284(5411): 143-7.
[9] PROCKOP D J, OH J Y. Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation [J]. Mol Ther, 2012, 20(1): 14-20.
[10] PARFENOVA H, LEFFLER C W, TCHERANOVA D, et al. Epileptic seizures increase circulating endothelial cells in peripheral blood as early indicators of cerebral vascular damage [J]. Am J Physiol Heart Circ Physiol, 2010, 298(6): H1687-98.
[11] WEI X, YANG X, HAN Z P, et al. Mesenchymal stem cells: a new trend for cell therapy [J]. Acta Pharmacol Sin, 2013, 34(6): 747-54.
[12] KANAZAWA H, FUJIMOTO Y, TERATANI T, et al. Bone marrow-derived mesenchymal stem cells ameliorate hepatic ischemia reperfusion injury in a rat model [J]. PLoS One, 2011, 6(4): e19195.
[13] NAGAYA N, KANGAWA K, ITOH T, et al. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy [J]. Circulation, 2005, 112(8): 1128-35.
[14] NINICHUK V, GROSS O, SEGERER S, et al. Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4A3-deficient mice [J]. Kidney Int, 2006, 70(1): 121-9.
[15] SAMSONRAJ R M, RAGHUNATH M, NURCOMBE V, et al. Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine [J]. Stem Cells Transl Med, 2017, 6(12): 2173-85.
[16] ZHAO K, LIU Q. The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation [J]. J Hematol Oncol, 2016, 9(1): 46.
[17] CHU D, DU M, HU X, et al. Paeoniflorin attenuates schistosomiasis japonica-associated liver fibrosis through inhibiting alternative activation of macrophages [J]. Parasitology, 2011, 138(10): 1259-71.
[18] MURPHY B S, BUSH H M, SUNDARESHAN V, et al. Characterization of macrophage activation states in patients with cystic fibrosis [J]. J Cyst Fibros, 2010, 9(5): 314-22.
[19] MURRAY L A, ROSADA R, MOREIRA A P, et al. Serum amyloid P therapeutically attenuates murine bleomycin-induced pulmonary fibrosis via its effects on macrophages [J]. PLoS One, 2010, 5(3): e9683.
[20] CAO Q, HARRIS D C, WANG Y. Macrophages in kidney injury, inflammation, and fibrosis [J]. Physiology (Bethesda), 2015, 30(3): 183-94.
[21] CAO Q, WANG Y, HARRIS D C. Macrophage heterogeneity, phenotypes, and roles in renal fibrosis [J]. Kidney Int Suppl (2011), 2014, 4(1): 16-9.
[22] CHOI H, LEE R H, BAZHANOV N, et al. Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-kappaB signaling in resident macrophages [J]. Blood, 2011, 118(2): 330-8.
[23] YANG C Y, CHANG P Y, CHEN J Y, et al. Adipose-derived mesenchymal stem cells attenuate dialysis-induced peritoneal fibrosis by modulating macrophage polarization via interleukin-6 [J]. Stem Cell Res Ther, 2021, 12(1): 193.
[24] MIZUNO M, ITO Y, HEPBURN N, et al. Zymosan, but not lipopolysaccharide, triggers severe and progressive peritoneal injury accompanied by complement activation in a rat peritonitis model [J]. J Immunol, 2009, 183(2): 1403-12.
[25] KIM H, MIZUNO M, FURUHASHI K, et al. Rat adipose tissue-derived stem cells attenuate peritoneal injuries in rat zymosan-induced peritonitis accompanied by complement activation [J]. Cytotherapy, 2014, 16(3): 357-68.
[26] SEKIGUCHI Y, HAMADA C, RO Y, et al. Differentiation of bone marrow-derived cells into regenerated mesothelial cells in peritoneal remodeling using a peritoneal fibrosis mouse model [J]. J Artif Organs, 2012, 15(3): 272-82.
[27] WANG N, LI Q, ZHANG L, et al. Mesenchymal stem cells attenuate peritoneal injury through secretion of TSG-6 [J]. PLoS One, 2012, 7(8): e43768.
[28] AROEIRA L S, AGUILERA A, SANCHEZ-TOMERO J A, et al. Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions [J]. J Am Soc Nephrol, 2007, 18(7): 2004-13.
[29] MARGETTS P J, BONNIAUD P, LIU L, et al. Transient overexpression of TGF-beta1 induces epithelial mesenchymal transition in the rodent peritoneum [J]. J Am Soc Nephrol, 2005, 16(2): 425-36.
[30] YANG A H, CHEN J Y, LIN J K. Myofibroblastic conversion of mesothelial cells [J]. Kidney Int, 2003, 63(4): 1530-9.
[31] STRIPPOLI R, MORENO-VICENTE R, BATTISTELLI C, et al. Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis [J]. Stem Cells Int, 2016, 2016(3543678.
[32] CANO A, PéREZ-MORENO M A, RODRIGO I, et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression [J]. Nat Cell Biol, 2000, 2(2): 76-83.
[33] YANG J, DAI C, LIU Y. A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition [J]. J Am Soc Nephrol, 2005, 16(1): 68-78.
[34] UENO T, NAKASHIMA A, DOI S, et al. Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-β1 signaling [J]. Kidney Int, 2013, 84(2): 297-307.
[35] ZOU X Z, LIU T, GONG Z C, et al. MicroRNAs-mediated epithelial-mesenchymal transition in fibrotic diseases [J]. Eur J Pharmacol, 2017, 796(190-206.
[36] YANAI K, ISHII H, AOMATSU A, et al. MicroRNAs in peritoneal fibrosis: a systematic review [J]. Discov Med, 2018, 26(145): 271-80.
[37] LI D, LU Z, LI X, et al. Human umbilical cord mesenchymal stem cells facilitate the up-regulation of miR-153-3p, whereby attenuating MGO-induced peritoneal fibrosis in rats [J]. J Cell Mol Med, 2018, 22(7): 3452-63.
[38] LIU B, GUAN Q, LI J, et al. Mesenchymal stroma cells in peritoneal dialysis effluents from patients [J]. Hum Cell, 2017, 30(2): 51-9.
[39] BASTUG F, GUNDUZ Z, TULPAR S, et al. Compare the effects of intravenous and intraperitoneal mesenchymal stem cell transplantation on ultrafiltration failure in a rat model of chronic peritoneal dialysis [J]. Ren Fail, 2014, 36(9): 1428-35.
[40] NAGASAKI K, NAKASHIMA A, TAMURA R, et al. Mesenchymal stem cells cultured in serum-free medium ameliorate experimental peritoneal fibrosis [J]. Stem Cell Res Ther, 2021, 12(1): 203.
[41] DYKSTRA J A, FACILE T, PATRICK R J, et al. Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose-Derived Stromal Vascular Fraction [J]. Stem Cells Transl Med, 2017, 6(4): 1096-108.
[42] COSTALONGA E C, FANELLI C, GARNICA M R, et al. Adipose-Derived Mesenchymal Stem Cells Modulate Fibrosis and Inflammation in the Peritoneal Fibrosis Model Developed in Uremic Rats [J]. Stem Cells Int, 2020, 2020(3768718.
[43] DALOUS J, LARGHERO J, BAUD O. Transplantation of umbilical cord-derived mesenchymal stem cells as a novel strategy to protect the central nervous system: technical aspects, preclinical studies, and clinical perspectives [J]. Pediatr Res, 2012, 71(4 Pt 2): 482-90.
[44] HUANG X Z, WEN D, ZHANG M, et al. Sirt1 activation ameliorates renal fibrosis by inhibiting the TGF-beta/Smad3 pathway [J]. J Cell Biochem, 2014, 115(5): 996-1005.
[45] GUO Y, WANG L, GOU R, et al. SIRT1-modified human umbilical cord mesenchymal stem cells ameliorate experimental peritoneal fibrosis by inhibiting the TGF-β/Smad3 pathway [J]. Stem Cell Res Ther, 2020, 11(1): 362.
[46] DU Y, ZONG M, GUAN Q, et al. Comparison of mesenchymal stromal cells from peritoneal dialysis effluent with those from umbilical cords: characteristics and therapeutic effects on chronic peritoneal dialysis in uremic rats [J]. Stem Cell Research & Therapy, 2021, 12(1):
[47] WANG N, SHAO Y, MEI Y, et al. Novel mechanism for mesenchymal stem cells in attenuating peritoneal adhesion: accumulating in the lung and secreting tumor necrosis factor α-stimulating gene-6 [J]. Stem Cell Res Ther, 2012, 3(6): 51.
[48] ALATAB S, SHEKARCHIAN S, NAJAFI I, et al. Systemic Infusion of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells in Peritoneal Dialysis Patients: Feasibility and Safety [J]. Cell J, 2019, 20(4): 483-95.
[49] JIANG H Y, WANG J P, BAI Y H, et al. Clinical observation of umbilical cord mesenchymal stem cell transplantation for treating patients receiving peritoneal dialysis [J]. Minerva Urol Nefrol, 2018, 70(1): 95-101.
[50] REN H, SANG Y, ZHANG F, et al. Comparative Analysis of Human Mesenchymal Stem Cells from Umbilical Cord, Dental Pulp, and Menstrual Blood as Sources for Cell Therapy [J]. Stem Cells Int, 2016, 2016(3516574.
[51] CIMINO M, GONCALVES R M, BARRIAS C C, et al. Xeno-Free Strategies for Safe Human Mesenchymal Stem/Stromal Cell Expansion: Supplements and Coatings [J]. Stem Cells Int, 2017, 2017(6597815.
[52] CESARZ Z, TAMAMA K. Spheroid Culture of Mesenchymal Stem Cells [J]. Stem Cells Int, 2016, 2016(9176357.
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