血液透析是慢性肾脏病进展至终末期最主要的替代治疗方法。据报道，血液透析患者中抑郁的发病率达20%～55%。近些年研究表明炎症因子在透析患者的病理生理机制上有重要作用，并对其抑郁的发生发展有影响，现就炎症因子在血液透析患者抑郁中的作用机制及其治疗相关进展进行综述。

Hemodialysis is the most important replacement treatment for chronic kidney disease progressed to end-stage renal disease. The incidence of depression has been reported to be 20～55% in hemodialysis patients. Recent studies have shown that inflammatory factors play important roles in hemodialysis patients, and have impacts on the presence and development of depression. This article reviews the research progresses in inflammatory factors in the pathogenesis of depression in hemodialysis patients and its treatment.