低氧诱导因子与肾纤维化关系的研究进展

闫桐; 贾新燕; 郭明好

doi:10.3969/j.issn.1671-4091.2024.02.011

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中国血液净化 >

2024 , Vol. 23 >Issue 02: 130 - 133

DOI: https://doi.org/10.3969/j.issn.1671-4091.2024.02.011

综述

低氧诱导因子与肾纤维化关系的研究进展

闫桐 ,
贾新燕 ,
郭明好

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453100 卫辉,1新乡医学院第一附属医院肾内科

收稿日期: 2023-10-23

修回日期: 2023-11-28

网络出版日期: 2024-02-12

基金资助

2020年度河南省医学科技攻关计划联合共建项目(LHGJ20200494)

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Research advances in the relationship between hypoxia-inducible factor-1α and renal fibrosis

YAN Tong ,
JIA Xin-Yan ,
GUO Ming-Hao

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Department of Nephrology, The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China

Received date: 2023-10-23

Revised date: 2023-11-28

Online published: 2024-02-12

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摘要

肾纤维化是各种肾脏疾病的共同病理特征,以进行性细胞外基质(extracellular matrix,ECM)堆积为特点。低氧诱导因子(hypoxia-inducible factor,HIF)是机体对缺氧反应的关键调节因子,通过调节ECM的合成。上皮-间充质转化(epithelial-mesenchymal transition,EMT)及多种信号转导通路发挥促纤维化作用。本文拟就HIF在肾纤维化中的研究进展进行综述。

关键词： 缺氧; 低氧诱导因子; 肾纤维化; 上皮-间充质转化

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闫桐 , 贾新燕 , 郭明好 . 低氧诱导因子与肾纤维化关系的研究进展[J]. 中国血液净化, 2024 , 23(02) : 130 -133 . DOI: 10.3969/j.issn.1671-4091.2024.02.011

Abstract

Renal fibrosis is the common pathological hallmark of various chronic kidney diseases, characterized by progressive accumulation of extracellular matrix (ECM). Hypoxia-inducible factor (HIF) is a key regulator of body’s response to hypoxia. HIF regulates ECM synthesis, epithelial-mesenchymal transition (EMT) and pro-fibrosis signaling pathways. This review summarized the relationship between HIF-1α and renal fibrosis.

Key words： Hypoxia; Hypoxia-inducible factor; Renal fibrosis; Epithelial-mesenchymal transition

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