连续性肾脏替代治疗(continuous renal replacement therapy，CRRT)期间净超滤(net ultrafiltration，UFNET)常用于治疗危重患者的容量过负荷(fluid overload，FO)，但UFNET强度对重症患者预后的影响尚不清楚。本文从容量负荷对危重患者的影响、不同强度UFNET对器官功能、死亡率、透析依赖等的影响，以及可能用于CRRT期间指导调整UFNET的潜在工具等方面进行综述，以引起临床医生对CRRT治疗期间最佳净超滤强度的关注。

Net ultrafiltration (UFNET) during continuous renal replacement therapy (CRRT) is often used to treat fluid overload (FO) in critically ill patients, but the effect of UFNET intensity on the prognosis of critically ill patients remains unclear. This article reviews the effects of FO on critically ill patients and the effects of different levels of UFNET on organ function, mortality, dialysis dependence, and potential tools that may be used to guide the adjustment of UFNET to draw clinicians' attention to the optimal UFNET intensity during CRRT treatment.