[an error occurred while processing this directive]
综述

巨噬细胞在血液透析用自体动静脉内瘘成熟与失功中的作用

  • 邹佳乐 ,
  • 迟雁青
展开
  • 050051 石家庄,1河北医科大学第三医院肾内科

收稿日期: 2024-04-08

  修回日期: 2024-10-23

  网络出版日期: 2025-01-12

基金资助

2022年度河北省优秀人才项目

The role of macrophages in the maturation and dysfunction of autogenous arteriovenous fistula for hemodialysis

  • ZOU Jia-Le ,
  • CHI Yan-Qing
Expand
  • Department of Nephrology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China

Received date: 2024-04-08

  Revised date: 2024-10-23

  Online published: 2025-01-12

摘要

炎症在自体动静脉内瘘(arteriovenous fistula,AVF)血管重塑的早期与晚期阶段均发挥着至关重要的调节作用。作为炎症反应中的重要免疫细胞之一,巨噬细胞具有在微环境中极化为炎症型(M1)和抗炎型(M2)等表型的能力。它们在炎症的发生、发展和消退过程中扮演着关键角色,并在AVF经历手术创伤下及血流动力学改变、缺氧和高脂血症等环境下能发挥重要调控作用,影响AVF的成熟或失功。目前,一些免疫抑制剂和他汀类药物已被证实能够减少巨噬细胞的浸润,从而改善AVF的通畅性。因此,深入了解巨噬细胞在AVF血管重塑中的作用,同时寻找更有效的调控巨噬细胞的方法可能成为提高AVF成熟率和保持通畅性的新方向。

本文引用格式

邹佳乐 , 迟雁青 . 巨噬细胞在血液透析用自体动静脉内瘘成熟与失功中的作用[J]. 中国血液净化, 2025 , 24(01) : 54 -57 . DOI: 10.3969/j.issn.1671-4091.2025.01.011

Abstract

Inflammation is known to play a crucial role in both early and late phases of vascular remodeling in arteriovenous fistula (AVF). Macrophages are pivotal immune cells in inflammatory responses and exhibit the ability to polarize into pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes in microenvironment. They play key roles in the initiation, progression and resolution of inflammation and in the modulation of AVF in response to surgical trauma, hemodynamic alterations, hypoxia and hyperlipidemia, thereby impacting the maturation and function of AVF. Currently, serval immunosuppressive agents and statins have been demonstrated to diminish macrophage infiltration, enable to improve AVF patency. Consequently, a comprehensive understanding of the roles of macrophages in AVF vascular remodeling is imperative. The exploration of more effective strategies for macrophage regulation may represent a novel avenue for enhancing maturity and maintaining patency of AVF.

参考文献

[1]金其庄,王玉柱,叶朝阳,等.中国血液透析用血管通路专家共识第 版[J].中国血液净化, 2019, 18(06):365-381 [2]Wong T, Chen Q, Zhong Q, et al.Cost-effectiveness analysis of autogenous arteriovenous fistula, arteriovenous graft, and tunneled-cuffed catheter for hemodialysis in patients with end-stage kidney disease in Southern China[J]. The Journal of Vascular Access, 2022: 11297298221143010. [3]Matsubara Y, Kiwan G, Fereydooni A, et al.Distinct subsets of T cells and macrophages impact venous remodeling during arteriovenous fistula maturation[J]. JVS-vascular science, 2020, 1: 207-218. [4]Kuwahara G, Hashimoto T, Tsuneki M, et al.CD44 promotes inflammation and extracellular matrix production during arteriovenous fistula maturation[J].Arteriosclerosis, thrombosis, and vascular biology, 2017, 37(6):1147-1156 [5]Stracke S, Konner K, K?stlin I, et al.Increased expression of TGF-β1 and IGF-I in inflammatory stenotic lesions of hemodialysis fistulas[J].Kidney international, 2002, 61(3):1011-1019 [6]Pourcet B, Staels B.Alternative macrophages in atherosclerosis: not always protective![J].The Journal of clinical investigation, 2018, 128(3):910-912 [7]Gordon S, Taylor P R.Monocyte and macrophage heterogeneity[J].Nature reviews immunology, 2005, 5(12):953-964 [8]Bian Z, Gong Y, Huang T, et al.Deciphering human macrophage development at single-cell resolution[J].Nature, 2020, 582(7813):571-576 [9]Lee S G, Oh J, Bong S K, et al.Macrophage polarization and acceleration of atherosclerotic plaques in a swine model[J].PLoS One, 2018, 13(3):e0193005- [10]Labonte A C, Tosello-Trampont A C, Hahn Y S.The role of macrophage polarization in infectious and inflammatory diseases[J].Molecules and cells, 2014, 37(4):275- [11]Mantovani A, Sozzani S, Locati M, et al.Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes[J].Trends in immunology, 2002, 23(11):549-555 [12]Shao B, Han B, Zeng Y, et al.The roles of macrophage autophagy in atherosclerosis[J].Acta Pharmacologica Sinica, 2016, 37(2):150-156 [13]Arora S, Dev K, Agarwal B, et al.Macrophages: Their role,activation and polarization in pulmonary diseases[J].Immunobiology, 2018, 223(4-5):383-396 [14]De Paoli F, Staels B, Chinetti-Gbaguidi G.Macrophage phenotypes and their modulation in atherosclerosis[J].Circulation Journal, 2014, 78(8):1775-1781 [15]Yanagita M, Kobayashi R, Murakami S.Nicotine can skew the characterization of the macrophage type-1 (MΦ1) phenotype differentiated with granulocyte-macrophage colony-stimulating factor to the MΦ2 phenotype[J].Biochemical and biophysical research communications, 2009, 388(1):91-95 [16]Gratchev A, Kzhyshkowska J, Kthe K, et al.Mphi1 and Mphi2 can be re-polarized by Th2 or Th1 cytokines,respectively,and respond to exogenous danger signals[J].Immunobiology, 2006, 211(6-8):473-486 [17]Shenoy S.Surgical technique determines the outcome of the BresciaCimino AVF[J].The Journal of Vascular Access, 2017, 18(1_suppl):S1-S4 [18]Brahmbhatt A, Remuzzi A, Franzoni M, et al.The molecular mechanisms of hemodialysis vascular access failure[J].Kidney international, 2016, 89(2):303-316 [19]Rai V, Agrawal D K.The role of damage-and pathogen-associated molecular patterns in inflammation-mediated vulnerability of atherosclerotic plaques[J].Canadian journal of physiology and pharmacology, 2017, 95(10):1245-1253 [20]Milioti N, Bermudez-Fajardo A, Penichet M L, et al.Antigen-induced immunomodulation in the pathogenesis of atherosclerosis[J]. Clinical and Developmental Immunology, 2008, 2008. [21]Liang A, Wang Y, Han G, et al.Chronic kidney disease accelerates endothelial barrier dysfunction in a mouse model of an arteriovenous fistula[J].American Journal of Physiology-Renal Physiology, 2013, 304(12):F1413-F1420 [22]Misra S, Fu A A, Rajan D K, et al.Expression of hypoxia inducible factor–1α,macrophage migration inhibition factor,matrix metalloproteinase–2 and? 9,and their inhibitors in hemodialysis grafts and arteriovenous fistulas[J].Journal of Vascular and Interventional Radiology, 2008, 19(2):252-259 [23]Asare Y, Schmitt M, Bernhagen J.The vascular biology of macrophage migration inhibitory factor (MIF)[J].Thrombosis and haemostasis, 2013, 109(03):391-398 [24]Lee T, Chauhan V, Krishnamoorthy M, et al.Severe venous neointimal hyperplasia prior to dialysis access surgery[J].Nephrology Dialysis Transplantation, 2011, 26(7):2264-2270 [25]Hu H, Patel S, Hanisch J J, et al.Future research directions to improve fistula maturation and reduce access failure[C]//Seminars in vascular surgery. WB Saunders, 2016, 29(4): 153-171. [26]Hentschel D M.Determinants of arteriovenous fistula maturation[J].Clinical Journal of the American Society of Nephrology: CJASN, 2018, 13(9):1307- [27]Samra G, Rai V, Agrawal D K.Innate and adaptive immune cells associate with arteriovenous fistula maturation and failure[J].Canadian Journal of Physiology and Pharmacology, 2022, 100(8):716-727 [28]Gorecka J, Fereydooni A, Gonzalez L, et al.Molecular targets for improving arteriovenous fistula maturation and patency[J].Vascular investigation and therapy, 2019, 2(2):33-41 [29]Kwak B R, B?ck M, Bochaton-Piallat M L, et al.Biomechanical factors in atherosclerosis: mechanisms and clinical implications[J].European heart journal, 2014, 35(43):3013-3020 [30]Browne L D, Bashar K, Griffin P, et al.The role of shear stress in arteriovenous fistula maturation and failure: a systematic review[J].PloS one, 2015, 10(12):e0145795- [31]Aoki T, Yamamoto K, Fukuda M, et al.Sustained expression of MCP-1 by low wall shear stress loading concomitant with turbulent flow on endothelial cells of intracranial aneurysm[J].Acta Neuropathol Commun, 2016, 4(1):48- [32]Aoki T, Fr?sen J, Fukuda M, et al.Prostaglandin E2EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms[J].Sci Signal, 2017, 10(465):100- [33]Ene-Iordache B, Remuzzi A.Disturbed flow in radialcephalic arteriovenous fistulae for haemodialysis: low and oscillating shear stress locates the sites of stenosis. Nephrol Dial Transplant 2012; 27:358-68. [34]De Wilde D, Trachet B, De Meyer G R Y, et al.Shear stress metrics and their relation to atherosclerosis: an in vivo follow-up study in atherosclerotic mice[J]. Annals of biomedical engineering, 2016, 44: 2327-2338. [35]Protack C D, Foster T R, Hashimoto T, et al.Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency[J].Scientific reports, 2017, 7(1):15386- [36]Korff T, Braun J, Pfaff D, et al.Role of ephrinB2 expression in endothelial cells during arteriogenesis: impact on smooth muscle cell migration and monocyte recruitment[J].Blood, The Journal of the American Society of Hematology, 2008, 112(1):73-81 [37]Fukuda D, Aikawa E, Swirski F K, et al.Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders[J].Proceedings of the national Academy of Sciences, 2012, 109(27):E1868-E1877 [38]Tarbell J, Mahmoud M, Corti A, et al.The role of oxygen transport in atherosclerosis and vascular disease[J].Journal of the Royal Society Interface, 2020, 17(165):20190732- [39]Pourcet B, Staels B.Alternative macrophages in atherosclerosis: not always protective![J].The Journal of clinical investigation, 2018, 128(3):910-912 [40]Fu H, Luo F, Yang L, et al.Hypoxia stimulates the expression of macrophage migration inhibitory factor in human vascular smooth muscle cells via HIF-1α dependent pathway[J]. BMC Cell Biology, 2010, 11: 1-13. [41]Wanner C, Tonelli M.KDIGO Clinical Practice Guideline for Lipid Management in CKD: summary of recommendation statements and clinical approach to the patient[J].Kidney international, 2014, 85(6):1303-1309 [42]Cozzolino M, Mangano M, Stucchi A, et al.Cardiovascular disease in dialysis patients[J].Nephrology Dialysis Transplantation, 2018, 33(suppl_3):i-i [43]Stevens S L, Hilgarth K, Ryan U S, et al.The synergistic effect of hypercholesterolemia and mechanical injury on intimal hyperplasia[J].Annals of vascular surgery, 1992, 6(1):55-61 [44]Wei S, Liu N, Fu Y, et al.Novel insights into modifiable risk factors for arteriovenous fistula failure and the importance of CKD lipid profile: A meta-analysis[J]. The Journal of Vascular Access, 2023: 11297298221115557. [45]Yang S, Yuan H Q, Hao Y M, et al.Macrophage polarization in atherosclerosis[J]. Clinica Chimica Acta, 2020, 501: 142-146. [46]Albany C J, Trevelin S C, Giganti G, et al.Getting to the heart of the matter: the role of regulatory T-cells (Tregs) in cardiovascular disease (CVD) and atherosclerosis[J]. Frontiers in immunology, 2019, 10: 2795. [47]Wong C Y, Bezhaeva T, Rothuizen T C, et al.Liposomal prednisolone inhibits vascular inflammation and enhances venous outward remodeling in a murine arteriovenous fistula model[J].Scientific reports, 2016, 6(1):30439- [48]Guo X, Fereydooni A, Isaji T, et al.Inhibition of the Akt1-mTORC1 axis alters venous remodeling to improve arteriovenous fistula patency[J].Scientific Reports, 2019, 9(1):11046- [49]Matsubara Y, Kiwan G, Liu J, et al.Inhibition of T-cells by cyclosporine a reduces macrophage accumulation to regulate venous adaptive remodeling and increase arteriovenous fistula maturation[J].Arteriosclerosis, thrombosis, and vascular biology, 2021, 41(3):e160-e174 [50]Corpataux J M, Naik J, Porter K E, et al.The effect of six different statins on the proliferation,migration,and invasion of human smooth muscle cells[J].Journal of Surgical Research, 2005, 129(1):52-56 [51]Yoshida M, Sawada T, Ishii H, et al.HMG-CoA reductase inhibitor modulates monocyte–endothelial cell interaction under physiological flow conditions in vitro: involvement of Rho GTPase–dependent mechanism[J].Arteriosclerosis, thrombosis, and vascular biology, 2001, 21(7):1165-1171 [52]Martinez L, Duque J C, Escobar L A, et al.Distinct impact of three different statins on arteriovenous fistula outcomes: a retrospective analysis[J].The journal of vascular access, 2016, 17(6):471-476 [53]Cui J, Kessinger C W, Jhajj H S, et al.Atorvastatin reduces in vivo fibrin deposition and macrophage accumulation,and improves primary patency duration and maturation of murine arteriovenous fistula[J].Journal of the American Society of Nephrology: JASN, 2020, 31(5):931-
文章导航

/

[an error occurred while processing this directive]