目的 分析终末期肾病患者眼部病变相关研究现状，挖掘研究热点及学科前沿。 方法 以CiteSpace文献分析软件对Web of Science核心数据库中近20年发表的相关文献进行分析、归纳、总结。 结果 共纳入相关文献307篇。终末期肾病患者眼部病变相关研究的发文量呈缓慢上升趋势；研究热点包括终末期肾病并发眼部症状、终末期肾病眼部病变的病理生理学机制以及透析患者的管理等(聚类模块值modularity，Q值=0.5308，聚类平均轮廓值silhouette，S值=0.8124)。研究前沿以血液透析治疗对患者眼部病变影响的相关研究为主。 结论 终末期肾病患者眼部病变领域相关的研究整体处于缓慢上升发展阶段，肾脏病学科以及眼学科等相关领域的研究者们可拓宽研究思路，多维度积极探索，为终末期肾病患者眼部病变的治疗、护理等发展及临床实践提供高质量证据支持。
Objective T o analyze the current research status of eye lesions in patients with end-stage renal disease, and to explore the hotspots and frontiers of research. Method CiteSpace literature analysis software was used to analyze, summarize, and generalize the relevant literature published in the Web of Science database in the past 20 years. Result A total of 307 relevant literature were included, and the number of publications on eye lesions in patients with end-stage renal disease is slowly increasing. The research hotspots include the study of eye symptoms, the pathological and physiological mechanisms of eye lesions in end-stage renal disease, and the management of dialysis patients. The research frontier mainly focuses on the impact of hemodialysis treatment on patients' eye lesions. Conclusion The overall research on eye lesions in patients with end-stage renal disease is in a slow upward development stage. Researchers in the fields of nephrology and ophthalmology can broaden their research ideas, actively explore from multiple perspectives, and provide high-quality evidence support for the development and clinical practice of eye lesions in patients with end-stage renal disease.
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