目的 探讨腹膜透析相关性腹膜炎中罕见贝纳柯克斯体感染的诊断与治疗方法。 方法 回顾性分析1例贝纳柯克斯体感染致难治性腹膜炎的临床资料并作文献回顾。 结果 患者腹腔引流液经MetaCAP病原微生物核酸高通量测序确诊病原体为贝纳柯克斯体，行双套管持续腹腔冲洗引流及多西环素口服治疗，腹腔引流液逐渐澄清，白细胞数下降。拔除引流管后随访2月腹膜炎未复发。 结论 在常规方法未能检出病原体时，MetaCAP测序可为腹膜透析相关性腹膜炎提供病原学依据并指导治疗。贝纳柯克斯体是导致腹膜透析相关性腹膜炎的少见的病原体，需及时识别并合理治疗。
Objective To explore the diagnosis and treatment of a rare Benacovirus infection in a patient with peritoneal dialysis-associated peritonitis. Methods A case of refractory peritoneal dialysis-related peritonitis caused by Benacovirus infection was retrospectively analyzed, and the related literature was reviewed. Results The pathogen of Benacovirus was identified by high-throughput sequencing of MetaCAP microbial nucleic acids from patient's peritoneal drainage fluid. Continuous peritoneal lavage and drainage using double-lumen tubes combined with oral administration of doxycycline gradually clarified the peritoneal drainage fluid and reduced white blood cell counts in the fluid. Follow-up for 2 months after removal of the drainage tube showed no recurrence. Conclusion When conventional methods fail to detect the pathogen, MetaCAP sequencing can be helpful to provide etiological evidence and treatment strategy for the peritoneal dialysis-associated peritonitis. Coxiella burnetii is a rare pathogen causing peritoneal dialysis-associated peritonitis, requiring prompt recognition and appropriate treatment.
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