Objective To investigate the influence of regular hemodialysis (HD), high-flux hemodialysis (HFD) and hemoperfusion (HP) on microinflammatory state in ESRD patients on maintenance hemodialysis (MHD). Methods We enrolled 48 patients with MHD for more than 6 months in this hospital and divided them randomly into HD group (n=16), HFD group (n=16) and HD+HP group (n=16). Serum CRP, IL-6 and TNF-α were measured by immunoturbidimetry and ELISA in patients before and after the first dialysis session, and after the treatment for 3 months, as well as in 20 healthy volunteers as normal controls. Results (a) Serum CRP, IL-6 and TNF-α were significantly higher in the 3 groups of patients than in normal controls (P<0.001), but had no differences among the 3 groups of patients before the treatment (P >0.05). (b) In HD group, serum CRP, IL-6 and TNF-α increased after first dialysis session and after the treatment for 3 months, but the increases were statistically insignificantly (P>0.05). (c) In HFD group serum CRP, IL-6 and TNF-α decreased after the first dialysis session, but the decreases were statistically insignificant (P> 0.05). After the treatment for 3 months, however, serum IL-6 and TNF-α levels decreased significantly (P<0.05) without change of serum CRP level (P>0.05). (d) In HD+HP group, serum IL-6 and TNF-α decreased after the first dialysis session (P<0.05) without change of serum CRP (P >0.05). After the treatment for 3 months, serum CRP, IL-6 and TNF-α decreased (P<0.01), but were still higher than those of normal control group. (e) After the treatment for 3 months, serum CRP, IL-6 and TNF-α were significantly lower in HD+HP group than in HFD group, and the extent of the decreases was larger in HD+HP group than in HFD group. Conclusions (a) Microinflammation state exists in ESRD patients on MHD. (b) The lowering of patients’ serum CRP, IL-6 and TNF-α and thus the recovery from microinflammatory state can be achieved by HFD and HP, and preferably by HP. (c) Patients’ microinflammatory state can not radically corrected after 3 months treatment, therefore, other measures and longer period of follow-up must be conducted for these patients.
ZHU Zheng-xi
,
LU Shao-qiang
,
LIANG Bi-qin
,
LU Feng-ling
,
NONG Cong
,
HUANG Hui
. The influence of various blood purification methods on microinflammatory state in patients with maintenance hemodialysis[J]. Chinese Journal of Blood Purification, 2011
, 10(1)
: 18
-21
.
DOI: 10.3969/j.issn.1671-4091.2011..00
