The effect of low molecular weight heparin as an antioxidant in chronic kidney disease

LIU Xiao-yan; ZHONG Yi-hong; DING Xiao-qiang

doi:10.3969/j.issn.1671-4091.2011.03.00

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Chinese Journal of Blood Purification >

2011 , Vol. 10 >Issue 3: 129 - 132

DOI: https://doi.org/10.3969/j.issn.1671-4091.2011.03.00

临床研究

The effect of low molecular weight heparin as an antioxidant in chronic kidney disease

LIU Xiao-yan ,
ZHONG Yi-hong ,
DING Xiao-qiang

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1Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; 2Department of Nephrology, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China

Received date: 2010-09-06

Revised date: 1900-01-01

Online published: 2011-03-12

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Abstract

Objective To identify the anti-oxidative effect of low molecular weight heparin (LMWH) in chronic kidney disease (CKD). Method Forty CKD patients at stage 3-5 were randomly divided into two groups, glutathione (GSH) group (0.9% NaCl 250ml + Glutathione 1.8g/d, intravenous injection for 10 days) and LMWH group (Fraxiparine 0.4ml/d, subcutaneous injection for 10 days). Plasma malondialdehyde (MDA), advanced oxidation protein product (AOPP) and glutathione peroxidase activity (GSH-PX) were measured at the beginning and the end of glutathione or LMWH administration. Results Plasma AOPP decreased and plasma GSH-PX increased significantly after the treatment in both LMWH and GSH groups (P<0.05). The decrease of plasma AOPP was more significant in GSH group than in LMWH group (2.86±0.82 vs. 4.89±0.66μmol/l, P<0.05). After the treatment, plasma MDA did not change significantly in LMWH group, but decreased (5.09±1.44 vs. 4.61±1.30nmol/ml, P<0.05) in GSH group. There were no apparent side effects in both groups. Conclusion LMWH ameliorates oxidative stress state without apparent side effects. The anti-oxidative effect of LMWH is slightly lower than that of GSH.

Key words： Chronic kidney disease; Low molecular weight heparin; Reduced glutathione

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LIU Xiao-yan , ZHONG Yi-hong , DING Xiao-qiang . The effect of low molecular weight heparin as an antioxidant in chronic kidney disease[J]. Chinese Journal of Blood Purification, 2011 , 10(3) : 129 -132 . DOI: 10.3969/j.issn.1671-4091.2011.03.00

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