Objective To study the prevalence of organ dysfunctions and the extent of organ damages in patients stung by wasps. Methods We recruited 57 cases stung by wasps and divided them into two groups based on the number of stings, group A with <5 stings (n=31) and group B with ≥5 stings (n=26). Their hemoglobin, liver function, renal function, and myocardial enzymes were measured, and the symptoms of organ dysfunctions were observed. Result In group A and group B, anemia was found in one case and 6 cases, neurological symptoms were detected in 0 case and 5 cases, renal damages in 1 case and 12 cases, liver dysfunctions in one case and 11 cases, myocardial injuries in 0 case and 11 cases, respectively; hemoglobin was 119.73±15.33g/L and 95.36±33.95g/L, CK was 59.75±40.60IU/L and 17659.27±29698.74IU/L, CK-MB 26.13±23.81U/L and 832.63±1053.24U/L, and AST 36.38±20.76U/L and 457.09±479.31U/L, respectively. All of the above parameters are statistically significant (P＜0.05) between the 2 groups. Serum creatinine was 102.53±45.13μmol/L and 326.53±454.63μmol/L in group A and group B, respectively, without statistical significance (P＞0.05) between the 2 groups. Conclusion Stings by wasps can induce multiple organ dysfunctions involving liver, kidney, nervous system and hematological system. Patients subjected to more wasp stings are prone to have severer extent of multiple organ dysfunctions.