Objective To investigate the prevalence of contrast-induced nephropathy (CIN) in patients using intravenous contrast medium for CT examination, and to explore the risk factors relating to CIN. Methods Inpatients with CT examination in Peking University People’s Hospital from January 2010 to June 2010 were studied retrospectively. We investigated the prevalence of CIN, and the risk factors for CIN were also characterized by using univariate and multifactor regression analyses. Results A total of 261 patients were involved in this study, of whom 7.7% patients developed CIN. Comparing with non-CIN group, CIN group showed higher rates of hypotension and liver cirrhosis. Multifactor regression analysis demonstrated that hypotension was the independent risk factor for CIN. Conclusion CIN was not uncommon in inpatients using low osmolarity contrast medium for CT examination. Hypotension was recognized as the independent risk factor after controlling the factors of renal function and contrast medium dose.