Objective To explore the clinic outcome and advantages of palindrome catheter as the chronic dialysis access. Methods We registered the patients treated with long-term indwelling catheterization in deep vein for hemodialysis (HD) blood access from May 1, 2009 to May 1, 2011 in our center. Dwelling time and complications were observed and compared between patients with palindrome catheter group and those with non-palindrome catheter group. Result Long-term indwelling catheter was implanted to 229 (234 times) patients with chronic renal failure. In palindrome catheter group (n=68), dwelling time was 381.08±44.61 days, and infection occurred 2 times (0.08 times/1000 catheter-days). Low blood flow occurred 23 times (0.5 times/1000 catheter-days), and 6 catheters were finally removed. In non-palindrome catheter group (n=166), dwelling time was 272.11±25.41 days, and infection occurred 19 times (0.42 times/1000 catheter-days). Low blood flow occurred 213 times (4.7 times/1000 catheter-days), and 21 catheters were finally removed. There are statistical differences between the two groups. In 6 cases in the palindrome catheter group, recirculation rate was zero and no low flow occurred on inverse connection. Conclusion Palindrome dialysis catheter is a better device for chronic HD patients because of longer dwelling time, lasting patency and lower infection rate.