【Abstract】Objective To investigate the clinically curative effects of different therapeutic methods of immunoadsorption (protein A immunoadsorption, PH350 immunoadsorption, DNA immunoadsorption) for systemic lupus erythematosus (SLE). Methods A total of 98 SLE patients were divided into three groups according to the immunoadsorption method used. Before and after the therapy, 24-hour urinary protein, serum creatinine (Cr), urea nitrogen (UN), albumin, immunoglobulin level, complement C3 and C4, autoantibodies (ANA and anti-dsDNA autoantibody) and SLEDAI score were measured. Results There were significant changes in 24-hour urinary protein, serum creatinine (Cr), urea nitrogen (UN), albumin, immunoglobulin level, autoantibodies (anti-dsDNA autoantibody), and SLEDAI score before and after the therapy (all P<0.05). Furthermore, the clearance of immunoglobulin was more efficient in protein A group than in PH350 group and DNA group (P<0.05). However, there were no differences in lupus activity control among patients using different immunoadsorption methods after longer period of observation. Conclusion The curative effects of immunoadsorption methods on SLE were significant. Among the immunoadsorption methods we used, protein A was more effective in autoantibody clearance. In clinical practice, a variety of factors should be considered in choosing the best immunoadsorption methods.