【Abstract】Objective To evaluate the safety and efficacy of PES14HF polyethersulfone high-flux dialyzer. Methods Seventy-two patients with stable end stage renal disease and receiving hemodialyis 3 times weekly were enrolled in this randomized parallel control study. High-flux hemodialysis was performed for 4h using PES14HF dialyzer (experiment group) or PES-150DS dialyzer (control group), and the study lasted for one week. The clearances of urea, creatinine, phosphate and β2-microglobulin were calculated. Reactions and adverse events were recorded. Results No significantly differences in serum level changes and clearances of urea, creatinine and phosphate were found between the 2 groups. β2-microglobulin clearance was significantly higher in experiment group (44.50±29.57ml/min) than in control group 25.75±11.27ml/min, P<0.05), so did the decrease magnitude of serum β2-microglobulin (38.87±12.48% vs. 29.53±17.71%, P<0.05). Urea clearance and the higher blood urea improved after the treatment in both groups, and the lowering of blood urea was more significant in experiment group (100%) than in control group (88.57%, P<0.05). Conclusion PES14HF dialyzer is efficient and safe for clinical application.
ZHANG Wei-ming
,
JIANG Geng-ru
,
QIAN Jia-qi
,
WANG Bing-shun
,
ZHU Chun
,
WANG Yong-mei
,
HUANG Hai-dong
,
YAN Yu-cheng
,
NI Zhao-hui.
. A randomized controlled clinical trial on safety and effectiveness of PES14HF polyethersulfone high-flux dialyzer in hemodialysis patients[J]. Chinese Journal of Blood Purification, 2010
, 9(8)
: 429
-432
.
DOI: 10.3969/j.issn.1671-4091.2010.08.009
