【Abstract】Objective To evaluate the value of multi-detector computed tomography venography (MDCTV) in the assessment of tunneled hemodialysis central vein catheters (TCCs) dysfunction. 　Method A total of 31 patients who had TCCs dysfunction without abnormality found by X-ray and ultrasound were enrolled. MDCTV was conducted to observe the position of catheters and to detect central venous stenosis, thrombosis, and fibrin sheath formation. Proper intervention was given according to MDCTV results.　Results MDCTV found catheter malposition in 10 cases, central venous stenosis in 5 cases, central venous thrombosis in 4 cases, fibrin sheath formation in 7 cases, and negative in 5 cases. The blood flow on hemodialysis reached over 300ml/min after proper interventions given.  Conclusion MDCTV provided a valuable way to evaluate dysfunction of TCCs.