【Abstract】Objective This report is based on the data (up to December 31, 2010) from Shanghai Renal Registry Network. Our aim is to explore the current status of dialysis in Shanghai.  Methods Data are collected from Shanghai Renal Registry Network in 2010. All of dialysis centers (n=63) in Shanghai enter the registry system.  Results The incidence of new dialysis patients was 1621 (114.8 patients per million), of which 75.8% were on hemodialysis (HD) and 24.2% on peritoneal dialysis (PD). The point prevalence of dialysis patients on Dec 31, 2010 is 10508 (744.0 patients per million), of which 80.6% were on hemodialysis (HD) and 19.4% on peritoneal dialysis (PD). The main cause for end stage renal disease (ESRD) is chronic glomerulonephritis. However, the incidence of diabetes is increasing from 17.2% to 19.5% within four years, and account for the second major cause for ESRD. Death rate is decreased from 8.4% in 2006 to 4.6% in 2010. Dialysis adequacy, hepatitis infection control and anemia treatment are improved.  Conclusions Dialysis population is continuously growing during recently years in Shanghai. Chronic glomerulonephritis is the main cause for ESRD patients. The main dialysis modality for ESRD patients is hemodialysis in Shanghai