【Abstract】 Objective To investigate the effect of high flux hemodialysis on nutrition and lipid metabolism in maintenance hemodialysis (MHD) patients. Methods A total of 60 MHD patients were randomly divided into two groups: high flux hemodialysis (HFHD) group, and low flux hemodialysis (LFHD) group. The treatment lasted for 6 months. Changes of the parameters for nutrition and lipid metabolism were observed before and after the treatment in the two groups. Results After 6 months, the Modified Quantitative Subjective Global Assessment score, EPO dose, β2-MG, hsCRP, iPTH, TG and apolipoprotein CIII were significantly lower in HFHD group than in LFHD group, and than in HFHD group before the treatment (P＜0.05), while ALB and IGF-1 were significantly higher (P＜0.05) in HFHD group. Conclusions   High flux hemodialysis can improve nutritional status and dyslipidema in MHD patients.