【Abstract】Purpose To explore the effects of integration of medical- nursing care on health- related knowledge and serum phosphorus in hemodialysis patients with hyperphosphatemia. Methods This study used a randomized controlled trial with 80 cases randomized into two groups. Results Serum phosphorus of the patients in the intervention group was 1.80±0.16 mmol/L, which was lower than that of the control group (2.06±0.15 mmol/L), and the difference was statistically significant (t=7.498 P＜0.001). In patients in the intervention group, the scores of disease knowledge (94.90 ± 1.45 vs. 92.78 ± 1.46, t=6.156, P＜0.001), diet knowledge (93.53±1.48 vs. 92.15±1.33, t=3.486, P＜0.001), medicine knowledge about hyperphosphatemia (93.90±1.39 vs. 92.45±1.28, t=4.853, P＜0.001), and sports knowledge (92.20±1.22 vs. 91.43±1.30, t=2.732, P=0.008) were higher as compared with those in patients in the control group. Conclusions Integration of medical-nursing care can improve health-related knowledge and reduce serum phosphorus in hemodialysis patients with hyperphosphatemia.