【Abstract】A variety of complications may happen in the processes of continuous renal replacement therapy (CRRT). Hypophosphatemia is a CRRT- related complication with higher incidence and serious consequences, and is becoming a critical issue to be solved. This paper reviews the literature about hypophosphatemia in CRRT patients, potential risk factors for CRRT-related hypophosphatemia, correlation of blood phosphorus level with the disease degree and death risks, and suggestions about phosphate supplement strategies and cost-effect analysis, in order to provide the useful information for medical staff to prevent and intervene CRRT-related hypophosphatemia.