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The effects of erythropoietin on renal fibrosis

  • ZHANG Xiang ,
  • CHEN Hong-Bo
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  • The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China; 2The first affiliated hospital,
    Zhejiang Provincial Hospital of Traditional Chinese Medicine, Hangzhou 310006, China

Received date: 2022-03-24

  Revised date: 2022-05-05

  Online published: 2022-07-12

Abstract

Renal fibrosis is a common end-stage pathological manifestation of chronic kidney disease
(CKD), and its severity is closely related to the prognosis of CKD. In recent years, some studies have found
that erythropoietin (EPO) is closely associated with the occurrence and development of renal fibrosis. As a regulator of red blood cell production, exogenous EPO supplementation can not only improve renal anemia, but
also improve renal function and effectively prevent and treat renal fibrosis. Therefore, this paper reviews the
role of EPO in renal fibrosis and its anti-fibrosis mechanism, providing new ideas for the application of EPO
in the treatment of renal fibrosis in the future.

Cite this article

ZHANG Xiang , CHEN Hong-Bo . The effects of erythropoietin on renal fibrosis[J]. Chinese Journal of Blood Purification, 2022 , 21(07) : 456 -468 . DOI: 10.3969/j.issn.1671-4091.2022.07.001

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